caa a22 4500 44534444X CHVBK 20180317142824.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00406-011-0195-5 doi (NATIONALLICENCE)springer-10.1007/s00406-011-0195-5 Sleep homeostasis in alcohol-dependent, depressed and healthy control men [Elektronische Daten] [Kirk Brower, Robert Hoffmann, Deirdre Conroy, J. Arnedt, Roseanne Armitage] Visually scored and power spectral analyses (PSA) of polysomnography (PSG) recordings reveal abnormalities in alcohol dependence (AD) and major depressive disorder (MDD), including deficiencies in slow wave activity (SWA) during non-rapid eye movement (NREM) sleep. SWA parameters reflect the integrity of the homeostatic sleep drive, which have not been compared in those with AD or MDD. Ten men with AD were compared with 10 men with MDD and 10 healthy controls (HCs), all aged 20-40years. They maintained an 11pm to 6 am sleep schedule for 5-7days, followed by 3 consecutive nights of PSG in the laboratory: night 1 for adaptation/screening; night 2 for baseline recordings; and night 3 as the challenge night, delaying sleep until 2 am. SWA was quantified with PSA across 4 NREM periods. Men with AD generated the least SWA at baseline. In response to sleep delay, HC men showed the expected SWA enhancement and a sharper exponential decline across NREM periods. Both the MDD and the AD groups showed a significantly blunted SWA response to sleep delay. Men with MDD had the least SWA in the first NREM period (impaired accumulation of sleep drive), whereas men with AD had the slowest SWA decay rate (impaired dissipation of sleep drive). These results suggest that both SWA generation and its homeostatic regulation are impaired in men with either AD or MDD. Finding interventions that selectively improve these different components of sleep homeostasis should be a goal of treatment for AD and MDD. Springer-Verlag, 2011 Alcohol dependence nationallicence Depression nationallicence Polysomnography nationallicence Sleep nationallicence Slow wave activity nationallicence Sleep homeostasis nationallicence Brower Kirk Department of Psychiatry, University of Michigan, 4250 Plymouth Rd, SPC 5740, 48109-2700, Ann Arbor, MI, USA aut Hoffmann Robert Department of Psychiatry, University of Michigan, 4250 Plymouth Rd, SPC 5766, 48109-2700, Ann Arbor, MI, USA aut Conroy Deirdre Department of Psychiatry, University of Michigan, 4250 Plymouth Rd, SPC 5740, 48109-2700, Ann Arbor, MI, USA aut Arnedt J. Department of Psychiatry, University of Michigan, 4250 Plymouth Rd, SPC 5766, 48109-2700, Ann Arbor, MI, USA aut Armitage Roseanne Department of Psychiatry, University of Michigan, 4250 Plymouth Rd, SPC 5766, 48109-2700, Ann Arbor, MI, USA aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/8(2011-12-01), 559-566 0940-1334 261:8<559 2011 261 406 https://doi.org/10.1007/s00406-011-0195-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0195-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brower Kirk Department of Psychiatry, University of Michigan, 4250 Plymouth Rd, SPC 5740, 48109-2700, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Hoffmann Robert Department of Psychiatry, University of Michigan, 4250 Plymouth Rd, SPC 5766, 48109-2700, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Conroy Deirdre Department of Psychiatry, University of Michigan, 4250 Plymouth Rd, SPC 5740, 48109-2700, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Arnedt J. Department of Psychiatry, University of Michigan, 4250 Plymouth Rd, SPC 5766, 48109-2700, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Armitage Roseanne Department of Psychiatry, University of Michigan, 4250 Plymouth Rd, SPC 5766, 48109-2700, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/8(2011-12-01), 559-566 0940-1334 261:8<559 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer