caa a22 4500 445344458 CHVBK 20180317142824.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00406-011-0201-y doi (NATIONALLICENCE)springer-10.1007/s00406-011-0201-y Clomipramine-induced serum prolactin as a marker for serotonin and dopamine turnover: results of an open label study [Elektronische Daten] [Joachim Cordes, Kai Kahl, Christian Werner, Uwe Henning, Gunnar Regenbrecht, Rolf Larisch, Christian Schmidt-Kraepelin, Johanna Thünker, Marcus Agelink, Stefan Löffler, Thomas Hohlfeld, Wolfgang Gaebel, Ansgar Klimke] Central nervous system (CNS) monoamine deficits have been linked to a number of pathological conditions such as major depressive disorder. Individual biological variations in 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) might account for the variation in responses of neurotransmitter systems observed after the administration of clomipramine. The prolactin response to clomipramine has been widely used to assess CNS functioning. This open label study investigates the prolactin response induced by clomipramine in the plasma of healthy volunteers and whether it is related to changes in monoamine metabolites. The effects of clomipramine challenge on prolactin, 5-HIAA, HVA and MHPG were measured in 12 healthy volunteers. Samples were drawn directly before and 50min after clomipramine infusion. A statistically significant increase in serum prolactin concentrations was measured in women 50min after CMI infusion, but not in men. We found no significant increases in the serum monoamine metabolite concentrations 50min after CMI infusion. Changes in HVA and 5-HIAA correlated statistically significantly and positively with the amount of prolactin release in the whole sample. Furthermore, positive correlations were found between ∆50-0 min 5-HIAA and ∆50-0 min HVA, although we did not find a correlation between ∆50-0 min prolactin and ∆50-0 min MHPG after clomipramine challenge. The pronounced prolactin release in healthy adult women might indicate a higher physiological sensitivity. Correlations between intra-individual changes in HVA, 5-HIAA and serum prolactin might indicate a central nervous effect of clomipramine on monoamine turnover. We conclude that monoamine changes in relation to prolactin response after clomipramine challenge may be suitable for characterizing the relationship between central serotonergic and dopaminergic function. Springer-Verlag, 2011 Clomipramine challenge nationallicence Homovanillic acid nationallicence Prolactin nationallicence Monoamine metabolites nationallicence Plasma nationallicence Cordes Joachim Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany aut Kahl Kai Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany aut Werner Christian Medical Department, Otsuka Pharma GmbH, Frankfurt, Germany aut Henning Uwe Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany aut Regenbrecht Gunnar Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany aut Larisch Rolf Department of Nuclear Medicine, Heinrich-Heine-University, Düsseldorf, Germany aut Schmidt-Kraepelin Christian Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany aut Thünker Johanna Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany aut Agelink Marcus Department of Psychiatry, Psychotherapy and Psychosomatic, Ruhr-University Bochum, Herford, Germany aut Löffler Stefan Department of Psychiatry, Psychotherapy, Offenbach, Germany aut Hohlfeld Thomas Institut für Pharmakologie und Klinische Pharmakologie, Heinrich-Heine-University, Düsseldorf, Germany aut Gaebel Wolfgang Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany aut Klimke Ansgar Department of Psychiatry, Psychotherapy, Offenbach, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/8(2011-12-01), 567-573 0940-1334 261:8<567 2011 261 406 https://doi.org/10.1007/s00406-011-0201-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0201-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cordes Joachim Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany aut NATIONALLICENCE 700 1- Kahl Kai Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany aut NATIONALLICENCE 700 1- Werner Christian Medical Department, Otsuka Pharma GmbH, Frankfurt, Germany aut NATIONALLICENCE 700 1- Henning Uwe Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany aut NATIONALLICENCE 700 1- Regenbrecht Gunnar Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany aut NATIONALLICENCE 700 1- Larisch Rolf Department of Nuclear Medicine, Heinrich-Heine-University, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Schmidt-Kraepelin Christian Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany aut NATIONALLICENCE 700 1- Thünker Johanna Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany aut NATIONALLICENCE 700 1- Agelink Marcus Department of Psychiatry, Psychotherapy and Psychosomatic, Ruhr-University Bochum, Herford, Germany aut NATIONALLICENCE 700 1- Löffler Stefan Department of Psychiatry, Psychotherapy, Offenbach, Germany aut NATIONALLICENCE 700 1- Hohlfeld Thomas Institut für Pharmakologie und Klinische Pharmakologie, Heinrich-Heine-University, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Gaebel Wolfgang Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany aut NATIONALLICENCE 700 1- Klimke Ansgar Department of Psychiatry, Psychotherapy, Offenbach, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/8(2011-12-01), 567-573 0940-1334 261:8<567 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer