caa a22 4500 445344474 CHVBK 20180317142824.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00406-011-0191-9 doi (NATIONALLICENCE)springer-10.1007/s00406-011-0191-9 The effect of low-dose omega 3 fatty acids on the treatment of mild to moderate depression in the elderly: a double-blind, randomized, placebo-controlled study [Elektronische Daten] [Yaser Tajalizadekhoob, Farshad Sharifi, Hossein Fakhrzadeh, Mojde Mirarefin, Maryam Ghaderpanahi, Zohre Badamchizade, Solaleh Azimipour] Due to the rise in the social and economic costs of depression, new antidepressant medication with fewer side effects should be found. Several studies have shown that an association exists between ω-3 polyunsaturated fatty acids (ω-3 PUFAs) and depression. However, this association has not been clear enough in the elderly with mild to moderate depression. Sixty-six inhabitants of Kahrizak Charity Foundation participated in this double-blind, randomized, placebo-controlled study. Each participant was≥65years of age, had a Mini Mental State Exam of≥22, and had scores ranging from 5 to 11 on the Geriatric Depression Scale-15 (GDS-15). During the 6months, the drug group was treated daily with one gram of fish oil capsule containing 300mg of both eicosapentaenoic acid and docosahexaenoic acid. No significant differences were noted between the groups in regard to level of education, use of antidepressant drugs, alcohol, tobacco use, history of chronic diseases, age, body mass index (BMI), high-sensitive C-reactive protein (hs-CRP), total cholesterol, and GDS-15 scores at baseline. After adjusting for cholesterol, BMI, and history of thyroid dysfunctions, a statistically significant difference was seen in GDS-15 scores between both groups. Furthermore, treatment with ω-3 PUFAs was clinically more effective in treating depression in comparison with the placebo. In this study, low-dose ω-3 PUFAs had some efficacy in the treatment of mild to moderate depression in elderly participants. Springer-Verlag, 2011 ω-3 polyunsaturated fatty acids nationallicence Fish oils nationallicence Depression nationallicence Elderly nationallicence Tajalizadekhoob Yaser Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th floor, Dr Shareeati Hospital, North Karegar Avenue, Tehran, Iran aut Sharifi Farshad Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th floor, Dr Shareeati Hospital, North Karegar Avenue, Tehran, Iran aut Fakhrzadeh Hossein Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th floor, Dr Shareeati Hospital, North Karegar Avenue, Tehran, Iran aut Mirarefin Mojde Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th floor, Dr Shareeati Hospital, North Karegar Avenue, Tehran, Iran aut Ghaderpanahi Maryam Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th floor, Dr Shareeati Hospital, North Karegar Avenue, Tehran, Iran aut Badamchizade Zohre Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th floor, Dr Shareeati Hospital, North Karegar Avenue, Tehran, Iran aut Azimipour Solaleh Rehabilitation Counseling Psychology, University of Texas at Southwestern Medical Center, Dallas, TX, USA aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/8(2011-12-01), 539-549 0940-1334 261:8<539 2011 261 406 https://doi.org/10.1007/s00406-011-0191-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0191-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tajalizadekhoob Yaser Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th floor, Dr Shareeati Hospital, North Karegar Avenue, Tehran, Iran aut NATIONALLICENCE 700 1- Sharifi Farshad Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th floor, Dr Shareeati Hospital, North Karegar Avenue, Tehran, Iran aut NATIONALLICENCE 700 1- Fakhrzadeh Hossein Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th floor, Dr Shareeati Hospital, North Karegar Avenue, Tehran, Iran aut NATIONALLICENCE 700 1- Mirarefin Mojde Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th floor, Dr Shareeati Hospital, North Karegar Avenue, Tehran, Iran aut NATIONALLICENCE 700 1- Ghaderpanahi Maryam Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th floor, Dr Shareeati Hospital, North Karegar Avenue, Tehran, Iran aut NATIONALLICENCE 700 1- Badamchizade Zohre Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th floor, Dr Shareeati Hospital, North Karegar Avenue, Tehran, Iran aut NATIONALLICENCE 700 1- Azimipour Solaleh Rehabilitation Counseling Psychology, University of Texas at Southwestern Medical Center, Dallas, TX, USA aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/8(2011-12-01), 539-549 0940-1334 261:8<539 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer