caa a22 4500 445344482 CHVBK 20180317142824.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00406-011-0205-7 doi (NATIONALLICENCE)springer-10.1007/s00406-011-0205-7 Clinically favourable effects of ketamine as an anaesthetic for electroconvulsive therapy: a retrospective study [Elektronische Daten] [Laura Kranaster, Jutta Kammerer-Ciernioch, Carolin Hoyer, Alexander Sartorius] In a retrospective chart review, we examined the effects of ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, as electroconvulsive therapy (ECT) anaesthetic in patients suffering from therapy-resistant depression. We included 42 patients who received ECT treatment with either ketamine (n=16) or the barbiturate thiopental (n=26). We analysed the number of sessions until completion of ECT treatment (used as a surrogate parameter for outcome), psychopathology as assessed by pre- and post-ECT Mini-Mental State Examination (MMSE) and Hamilton Rating Scale for Depression (HAM-D) scores as well as ECT and seizure parameters (stimulation dose, seizure duration and concordance, urapidil dosage for post-seizure blood pressure management). The ketamine group needed significantly fewer ECT sessions and had significantly lower HAM-D and higher MMSE scores afterwards. As expected, the ketamine group needed more urapidil for blood pressure control. Taking into account the limits inherent in a retrospective study design and the rather small sample size, our results nonetheless point towards synergistic effects of ECT and ketamine anaesthesia, less cognitive side effects and good tolerability of ketamine. Springer-Verlag, 2011 ECT nationallicence Ketamine nationallicence Depression nationallicence Cognition nationallicence Kranaster Laura Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Ruprecht-Karls-University Heidelberg, J5, 68159, Mannheim, Germany aut Kammerer-Ciernioch Jutta Department of General Psychiatry and Psychotherapy, Psychiatric Centre Nordbaden, Wiesloch, Germany aut Hoyer Carolin Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Ruprecht-Karls-University Heidelberg, J5, 68159, Mannheim, Germany aut Sartorius Alexander Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Ruprecht-Karls-University Heidelberg, J5, 68159, Mannheim, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/8(2011-12-01), 575-582 0940-1334 261:8<575 2011 261 406 https://doi.org/10.1007/s00406-011-0205-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0205-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kranaster Laura Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Ruprecht-Karls-University Heidelberg, J5, 68159, Mannheim, Germany aut NATIONALLICENCE 700 1- Kammerer-Ciernioch Jutta Department of General Psychiatry and Psychotherapy, Psychiatric Centre Nordbaden, Wiesloch, Germany aut NATIONALLICENCE 700 1- Hoyer Carolin Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Ruprecht-Karls-University Heidelberg, J5, 68159, Mannheim, Germany aut NATIONALLICENCE 700 1- Sartorius Alexander Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Ruprecht-Karls-University Heidelberg, J5, 68159, Mannheim, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/8(2011-12-01), 575-582 0940-1334 261:8<575 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer