caa a22 4500 445344490 CHVBK 20180317142824.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00406-010-0183-1 doi (NATIONALLICENCE)springer-10.1007/s00406-010-0183-1 Different gray matter patterns in chronic schizophrenia and chronic bipolar disorder patients identified using voxel-based morphometry [Elektronische Daten] [Vicente Molina, Gemma Galindo, Benjamín Cortés, Alba de Herrera, Ana Ledo, Javier Sanz, Carlos Montes, Juan Hernández-Tamames] Gray matter (GM) volume deficits have been described in patients with schizophrenia (Sz) and bipolar disorder (BD), but to date, few studies have directly compared GM volumes between these syndromes with methods allowing for whole-brain comparisons. We have used structural magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) to compare GM volumes between 38 Sz and 19 BD chronic patients. We also included 24 healthy controls. The results revealed a widespread cortical (dorsolateral and medial prefrontal and precentral) and cerebellar deficit as well as GM deficits in putamen and thalamus in Sz when compared to BD patients. Besides, a subcortical GM deficit was shown by Sz and BD groups when compared to the healthy controls, although a putaminal reduction was only evident in the Sz patients. In this comparison, the BD patients showed a limited cortical and subcortical GM deficit. These results support a partly different pattern of GM deficits associated to chronic Sz and chronic BD, with some degree of overlapping. Springer-Verlag, 2010 Schizophrenia nationallicence Bipolar disorder nationallicence Gray matter nationallicence Voxel-based morphometry nationallicence Molina Vicente Department of Psychiatry, Hospital Universitario de Salamanca, Paseo de San Vicente, 58-182, 37007, Salamanca, Spain aut Galindo Gemma Department of Psychiatry, Hospital Universitario de Salamanca, Paseo de San Vicente, 58-182, 37007, Salamanca, Spain aut Cortés Benjamín Department of Psychiatry, Hospital Universitario de Salamanca, Paseo de San Vicente, 58-182, 37007, Salamanca, Spain aut de Herrera Alba Medical Imaging Laboratory, Universidad Rey Juan Carlos, Madrid, Spain aut Ledo Ana Department of Psychiatry, Hospital Clínico de Valladolid, Valladolid, Spain aut Sanz Javier Department of Psychiatry, Hospital Doce de Octubre, Madrid, Spain aut Montes Carlos Department of Radiophysics, Hospital Universitario de Salamanca, Salamanca, Spain aut Hernández-Tamames Juan Medical Imaging Laboratory, Universidad Rey Juan Carlos, Madrid, Spain aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/5(2011-08-01), 313-322 0940-1334 261:5<313 2011 261 406 https://doi.org/10.1007/s00406-010-0183-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0183-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Molina Vicente Department of Psychiatry, Hospital Universitario de Salamanca, Paseo de San Vicente, 58-182, 37007, Salamanca, Spain aut NATIONALLICENCE 700 1- Galindo Gemma Department of Psychiatry, Hospital Universitario de Salamanca, Paseo de San Vicente, 58-182, 37007, Salamanca, Spain aut NATIONALLICENCE 700 1- Cortés Benjamín Department of Psychiatry, Hospital Universitario de Salamanca, Paseo de San Vicente, 58-182, 37007, Salamanca, Spain aut NATIONALLICENCE 700 1- de Herrera Alba Medical Imaging Laboratory, Universidad Rey Juan Carlos, Madrid, Spain aut NATIONALLICENCE 700 1- Ledo Ana Department of Psychiatry, Hospital Clínico de Valladolid, Valladolid, Spain aut NATIONALLICENCE 700 1- Sanz Javier Department of Psychiatry, Hospital Doce de Octubre, Madrid, Spain aut NATIONALLICENCE 700 1- Montes Carlos Department of Radiophysics, Hospital Universitario de Salamanca, Salamanca, Spain aut NATIONALLICENCE 700 1- Hernández-Tamames Juan Medical Imaging Laboratory, Universidad Rey Juan Carlos, Madrid, Spain aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/5(2011-08-01), 313-322 0940-1334 261:5<313 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer