caa a22 4500 445344539 CHVBK 20180317142824.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00406-011-0189-3 doi (NATIONALLICENCE)springer-10.1007/s00406-011-0189-3 BDNF serum levels, but not BDNF Val66Met genotype, are correlated with personality traits in healthy subjects [Elektronische Daten] [Alessandra Minelli, Roberta Zanardini, Cristian Bonvicini, Riccardo Sartori, Laura Pedrini, Massimo Gennarelli, Luisella Bocchio-Chiavetto] Consisting evidence in animal models has suggested that alterations in brain-derived neurotrophic factor (BDNF) brain expression and release are involved in the pathogenesis of mental illnesses, such as, mood, anxiety, and eating disorders. This hypothesis is supported by data emerging from biochemical studies on serum BDNF levels and genetic studies on the functional polymorphism Val66Met in the BDNF gene in patients and control subjects. Anxiety-related personality traits are associated with several mental disorders. However, they are also measurable in non-affected subjects and, so, may represent a useful "endophenotype” to study the biological correlation of the vulnerability factors in the general population. In this study, we analyzed putative correlations in subjects unaffected by mental disorders between personality traits, serum BDNF levels (N=107), and the BDNF Val66Met genotype (N=217). Furthermore, we tested the possible interactions between these variables. A significant correlation has been observed between high scores of harm avoidance (HA) measured by the temperament and character inventory (TCI), and low BDNF serum concentration (r=−0.253, P=0.009). In addition, an association has been evidenced between low BDNF levels in serum and the BDNF Val/Val genotype (P=0.021). By analyzing putative concomitant effects of different variables on HA scores in a regression model, we observed a significant correlation only with BDNF serum concentrations (P=0.022). The study results suggest that a decrease in serum BDNF concentrations may represent a biochemical marker associated with anxiety personality traits also retrievable in the general population. Springer-Verlag, 2011 BDNF nationallicence Depression nationallicence Harm Avoidance nationallicence Healthy volunteers nationallicence Temperament and character inventory nationallicence Minelli Alessandra Genetic Unit, I.R.C.C.S. "San Giovanni di Dio” Fatebenefratelli, Via Pilastroni, 4, Brescia, Italy aut Zanardini Roberta Neuropsychopharmacology Unit, I.R.C.C.S. "San Giovanni di Dio” Fatebenefratelli, Via Pilastroni, 4, Brescia, Italy aut Bonvicini Cristian Genetic Unit, I.R.C.C.S. "San Giovanni di Dio” Fatebenefratelli, Via Pilastroni, 4, Brescia, Italy aut Sartori Riccardo Department of Philosophy, Education, Psychology, University of Verona, Lungadige Porta Vittoria, 17, Verona, Italy aut Pedrini Laura Psychiatric Unit, I.R.C.C.S. "San Giovanni di Dio” Fatebenefratelli, Via Pilastroni, 4, Brescia, Italy aut Gennarelli Massimo Genetic Unit, I.R.C.C.S. "San Giovanni di Dio” Fatebenefratelli, Via Pilastroni, 4, Brescia, Italy aut Bocchio-Chiavetto Luisella Neuropsychopharmacology Unit, I.R.C.C.S. "San Giovanni di Dio” Fatebenefratelli, Via Pilastroni, 4, Brescia, Italy aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/5(2011-08-01), 323-329 0940-1334 261:5<323 2011 261 406 https://doi.org/10.1007/s00406-011-0189-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0189-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Minelli Alessandra Genetic Unit, I.R.C.C.S. "San Giovanni di Dio” Fatebenefratelli, Via Pilastroni, 4, Brescia, Italy aut NATIONALLICENCE 700 1- Zanardini Roberta Neuropsychopharmacology Unit, I.R.C.C.S. "San Giovanni di Dio” Fatebenefratelli, Via Pilastroni, 4, Brescia, Italy aut NATIONALLICENCE 700 1- Bonvicini Cristian Genetic Unit, I.R.C.C.S. "San Giovanni di Dio” Fatebenefratelli, Via Pilastroni, 4, Brescia, Italy aut NATIONALLICENCE 700 1- Sartori Riccardo Department of Philosophy, Education, Psychology, University of Verona, Lungadige Porta Vittoria, 17, Verona, Italy aut NATIONALLICENCE 700 1- Pedrini Laura Psychiatric Unit, I.R.C.C.S. "San Giovanni di Dio” Fatebenefratelli, Via Pilastroni, 4, Brescia, Italy aut NATIONALLICENCE 700 1- Gennarelli Massimo Genetic Unit, I.R.C.C.S. "San Giovanni di Dio” Fatebenefratelli, Via Pilastroni, 4, Brescia, Italy aut NATIONALLICENCE 700 1- Bocchio-Chiavetto Luisella Neuropsychopharmacology Unit, I.R.C.C.S. "San Giovanni di Dio” Fatebenefratelli, Via Pilastroni, 4, Brescia, Italy aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/5(2011-08-01), 323-329 0940-1334 261:5<323 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer