caa a22 4500 445344547 CHVBK 20180317142824.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00406-010-0175-1 doi (NATIONALLICENCE)springer-10.1007/s00406-010-0175-1 The Inventory of Depressive Symptomatology (IDS-C28) is more sensitive to changes in depressive symptomatology than the Hamilton Depression Rating Scale (HAMD17) in patients with mild major, minor or subsyndromal depression [Elektronische Daten] [Isabella Helmreich, Stefanie Wagner, Roland Mergl, Antje-Kathrin Allgaier, Martin Hautzinger, Verena Henkel, Ulrich Hegerl, André Tadić] Depression rating scales play a decisive role in the assessment of the severity of depression and the evaluation of the efficacy of antidepressant treatments. The Hamilton Depression Rating Scale (HAMD) is regarded as the ‘gold standard'; nevertheless, studies suggest that the Inventory of Depressive Symptomatology (IDS) is more sensitive to detect symptom changes. The aim of the present study was to investigate whether the IDS is more sensitive in detecting changes in depression symptoms in patients with mild major, minor or subsyndromal depression (MIND). Biweekly IDS-C28 and HAMD17 data from 340 patients of a 10-week randomized, placebo-controlled trial comparing the effectiveness of sertraline and cognitive-behavioural therapy in patients with MIND were analysed. We investigated sensitivity to change for both scales (1) from assessment-to-assessment, (2) in relation to depression severity level, and (3) in relation to DSM-IV depression criterion symptoms. The IDS-C28 was more sensitive in detecting changes in depression symptomatology over the treatment course as well as for different severity levels, especially in patients with a low depression severity. It assesses the DSM-IV criteria more thoroughly, is better able to track the change of cognitive symptoms and to identify residual symptoms. Both scales are well able to assess depressive symptomatology. However, the IDS-C28 surpasses the HAMD17 in detecting small changes especially in the core symptoms of depression. This is important for an optimal treatment by capturing early improvements, enabling prompt reactions and detecting residual symptoms. Springer-Verlag, 2010 Minor depression nationallicence Hamilton Depression Rating Scale (HAMD17) nationallicence Inventory of Depressive Symptomatology (IDS-C28) nationallicence Sensitivity to change nationallicence Depression severity nationallicence Helmreich Isabella Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Strasse 8, 5131, Mainz, Germany aut Wagner Stefanie Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Strasse 8, 5131, Mainz, Germany aut Mergl Roland Department of Psychiatry, University of Leipzig, Leipzig, Germany aut Allgaier Antje-Kathrin Department of Child and Adolescent Psychiatry, Ludwig-Maximilians-University, Munich, Germany aut Hautzinger Martin Institute of Psychology, Department of Clinical and Developmental Psychology, University of Tuebingen, Tuebingen, Germany aut Henkel Verena Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany aut Hegerl Ulrich Department of Psychiatry, University of Leipzig, Leipzig, Germany aut Tadić André Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Strasse 8, 5131, Mainz, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/5(2011-08-01), 357-367 0940-1334 261:5<357 2011 261 406 https://doi.org/10.1007/s00406-010-0175-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0175-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Helmreich Isabella Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Strasse 8, 5131, Mainz, Germany aut NATIONALLICENCE 700 1- Wagner Stefanie Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Strasse 8, 5131, Mainz, Germany aut NATIONALLICENCE 700 1- Mergl Roland Department of Psychiatry, University of Leipzig, Leipzig, Germany aut NATIONALLICENCE 700 1- Allgaier Antje-Kathrin Department of Child and Adolescent Psychiatry, Ludwig-Maximilians-University, Munich, Germany aut NATIONALLICENCE 700 1- Hautzinger Martin Institute of Psychology, Department of Clinical and Developmental Psychology, University of Tuebingen, Tuebingen, Germany aut NATIONALLICENCE 700 1- Henkel Verena Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany aut NATIONALLICENCE 700 1- Hegerl Ulrich Department of Psychiatry, University of Leipzig, Leipzig, Germany aut NATIONALLICENCE 700 1- Tadić André Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Untere Zahlbacher Strasse 8, 5131, Mainz, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/5(2011-08-01), 357-367 0940-1334 261:5<357 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer