caa a22 4500 445344571 CHVBK 20180317142825.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00406-011-0259-6 doi (NATIONALLICENCE)springer-10.1007/s00406-011-0259-6 General and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders: a report by the WPA section of pharmacopsychiatry [Elektronische Daten] [Thomas Baghai, Pierre Blier, David Baldwin, Michael Bauer, Guy Goodwin, Kostas Fountoulakis, Siegfried Kasper, Brian Leonard, Ulrik Malt, Dan Stein, Marcio Versiani, Hans-Jürgen Möller] Current gold standard approaches to the treatment of depression include pharmacotherapeutic and psychotherapeutic interventions with social support. Due to current controversies concerning the efficacy of antidepressants in randomized controlled trials, the generalizability of study findings to wider clinical practice and the increasing importance of socioeconomic considerations, it seems timely to address the uncertainty of concerned patients and relatives, and their treating psychiatrists and general practitioners. We therefore discuss both the efficacy and clinical effectiveness of antidepressants in the treatment of depressive disorders. We explain and clarify useful measures for assessing clinically meaningful antidepressant treatment effects and the types of studies that are useful for addressing uncertainties. This includes considerations of methodological issues in randomized controlled studies, meta-analyses, and effectiveness studies. Furthermore, we summarize the differential efficacy and effectiveness of antidepressants with distinct pharmacodynamic properties, and differences between studies using antidepressants and/or psychotherapy. We also address the differential effectiveness of antidepressant drugs with differing modes of action and in varying subtypes of depressive disorder. After highlighting the clinical usefulness of treatment algorithms and the divergent biological, psychological, and clinical efforts to predict the effectiveness of antidepressant treatments, we conclude that the spectrum of different antidepressant treatments has broadened over the last few decades. The efficacy and clinical effectiveness of antidepressants is statistically significant, clinically relevant, and proven repeatedly. Further optimization of treatment can be helped by clearly structured treatment algorithms and the implementation of psychotherapeutic interventions. Modern individualized antidepressant treatment is in most cases a well-tolerated and efficacious approach to minimize the negative impact of otherwise potentially devastating and life-threatening outcomes in depressive disorders. Springer-Verlag, 2011 Antidepressant treatments nationallicence Depression nationallicence Pharmacological treatments nationallicence Psychotherapy nationallicence Baghai Thomas Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Nußbaumstraße 7, 80336, Munich, Germany aut Blier Pierre Department of Psychiatry, University of Ottawa, Ottawa, Canada aut Baldwin David University Department of Psychiatry, University of Southampton, Southampton, UK aut Bauer Michael University Hospital Carl Gustav Carus, Dresden, Germany aut Goodwin Guy University Department, Warneford Hospital, Oxford, UK aut Fountoulakis Kostas 3rd Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece aut Kasper Siegfried Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria aut Leonard Brian National University of Ireland, Galway, Ireland aut Malt Ulrik Department of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital, Oslo, Norway aut Stein Dan MRC Unit of Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa aut Versiani Marcio Department of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil aut Möller Hans-Jürgen Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Nußbaumstraße 7, 80336, Munich, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261(2011-11-01), 207-245 0940-1334 261<207 2011 261 406 https://doi.org/10.1007/s00406-011-0259-6 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0259-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Baghai Thomas Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Nußbaumstraße 7, 80336, Munich, Germany aut NATIONALLICENCE 700 1- Blier Pierre Department of Psychiatry, University of Ottawa, Ottawa, Canada aut NATIONALLICENCE 700 1- Baldwin David University Department of Psychiatry, University of Southampton, Southampton, UK aut NATIONALLICENCE 700 1- Bauer Michael University Hospital Carl Gustav Carus, Dresden, Germany aut NATIONALLICENCE 700 1- Goodwin Guy University Department, Warneford Hospital, Oxford, UK aut NATIONALLICENCE 700 1- Fountoulakis Kostas 3rd Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Kasper Siegfried Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Leonard Brian National University of Ireland, Galway, Ireland aut NATIONALLICENCE 700 1- Malt Ulrik Department of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Stein Dan MRC Unit of Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa aut NATIONALLICENCE 700 1- Versiani Marcio Department of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil aut NATIONALLICENCE 700 1- Möller Hans-Jürgen Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Nußbaumstraße 7, 80336, Munich, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261(2011-11-01), 207-245 0940-1334 261<207 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer