caa a22 4500 44534458X CHVBK 20180317142825.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00406-010-0116-z doi (NATIONALLICENCE)springer-10.1007/s00406-010-0116-z Increased plasma levels of soluble TNF receptor I in patients with bipolar disorder [Elektronische Daten] [Izabela Barbosa, Rodrigo Huguet, Vanessa Mendonça, Lirlândia Sousa, Fernando Neves, Moisés Bauer, Antônio Teixeira] Bipolar disorder (BD) has been associated with a proinflammatory state in which TNF-α seems to play a relevant role. The aim of the present study was to evaluate the plasma levels of TNF-α and its soluble receptors (sTNFR1 and sTNFR2) in BD patients in mania and euthymia in comparison with control subjects. We evaluated 53 BD patients (34 in mania and 19 in euthymia) and 38 healthy subjects. All subjects were assessed by the Mini-International Neuropsychiatry Interview (MINI-Plus). Patients were also evaluated by the Young Mania Rating Scale (YMRS) and by Hamilton Depression Rating Scale (HDRS). Plasma TNF-α and its soluble receptors were measured by ELISA. The plasma TNF-α and sTNFR2 levels did not differ between groups, but higher sTNFR1 levels were found in BD patients. Of note, BD patients in mania had higher sTNFR1 levels than BD patients in euthymia and controls. The sTNFR1 and sTNFR2 levels correlated with BD duration, and sTNFR2 levels correlated with age of patients. Our data indicate a proinflammatory status in BD patients during mania and further suggest that inflammatory mechanisms may be involved with the physiopathology of BD. Springer-Verlag, 2010 Bipolar disorder nationallicence Cytokines nationallicence Inflammation nationallicence TNF-alpha nationallicence Soluble TNF receptors nationallicence Barbosa Izabela Neuroscience Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil aut Huguet Rodrigo Neuroscience Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil aut Mendonça Vanessa Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, UFMG, Belo Horizonte, Brazil aut Sousa Lirlândia Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, UFMG, Belo Horizonte, Brazil aut Neves Fernando Department of Mental Health, School of Medicine, UFMG, Belo Horizonte, Brazil aut Bauer Moisés Laboratory of Cellular and Molecular Immunology, Institute of Biomedical Research and Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil aut Teixeira Antônio Neuroscience Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/2(2011-03-01), 139-143 0940-1334 261:2<139 2011 261 406 https://doi.org/10.1007/s00406-010-0116-z text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0116-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barbosa Izabela Neuroscience Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil aut NATIONALLICENCE 700 1- Huguet Rodrigo Neuroscience Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil aut NATIONALLICENCE 700 1- Mendonça Vanessa Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, UFMG, Belo Horizonte, Brazil aut NATIONALLICENCE 700 1- Sousa Lirlândia Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, UFMG, Belo Horizonte, Brazil aut NATIONALLICENCE 700 1- Neves Fernando Department of Mental Health, School of Medicine, UFMG, Belo Horizonte, Brazil aut NATIONALLICENCE 700 1- Bauer Moisés Laboratory of Cellular and Molecular Immunology, Institute of Biomedical Research and Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil aut NATIONALLICENCE 700 1- Teixeira Antônio Neuroscience Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/2(2011-03-01), 139-143 0940-1334 261:2<139 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer