caa a22 4500 44534461X CHVBK 20180317142825.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00406-010-0121-2 doi (NATIONALLICENCE)springer-10.1007/s00406-010-0121-2 S100B and homocysteine in the acute alcohol withdrawal syndrome [Elektronische Daten] [Dirk Wedekind, Karolin Neumann, Peter Falkai, Berend Malchow, Kirsten Engel, Katja Jamrozinski, Ursula Havemann-Reinecke] Elevations of serum homocysteine levels are a consistent finding in alcohol addiction. Serum S100B levels are altered in different neuropsychiatric disorders but not well investigated in alcohol withdrawal syndromes. Because of the close connection of S100B to ACTH and glutamate secretion that both are involved in neurodegeneration and symptoms of alcoholism the relationship of S100B and homocysteine to acute withdrawal variables has been examined. A total of 22 male and 9 female inpatients (mean age 46.9±9.7years) with an ICD-10 diagnosis of alcohol addiction without relevant affective comorbidity were examined on admission and after 24, 48, and 120h during withdrawal. S100B and homocysteine levels in serum were collected, and severity of withdrawal symptoms (AWS-scale), applied withdrawal medication, initial serum ethanol levels and duration of addiction were recorded. Serum S100B and homocysteine levels declined significantly (P<.05) over time. Both levels declined with withdrawal syndrome severity. Females showed a trend to a more intense decline in serum S100B levels compared to males at day 5 (P=.06). Homocysteine levels displayed a negative relationship to applied amount of clomethiazole (P<.05) and correlated with age of onset of addiction. No withdrawal seizures were recorded during the trial. As it is known for homocysteine, S100B revealed to decline rapidly over withdrawal treatment in alcoholism. This effect is more pronounced in female patients. S100B could be of relevance in the neurobiology of alcohol withdrawal syndromes. It may be indirectly related to the level of stress level or glutamatergic activity during alcohol withdrawal. The Author(s), 2010 Alcohol addiction nationallicence Homocysteine nationallicence S100B nationallicence Withdrawal nationallicence ACTH : Adrenocorticotropin nationallicence AWS-scale : Acute withdrawal-scale nationallicence ELISA : Enzyme-linked-immuno-sorbent-assay nationallicence GABA : Gamma-amino-butyric acid nationallicence HPA : Hypothalamo-pituitary-adrenomedullary (axis) nationallicence HRP : Horseradish-peroxydase nationallicence ICD-10 : International classification of diseases, 10th revision nationallicence kDA : kilo-Dalton nationallicence MALT : Munich alcoholism test nationallicence MRI : Magnetic resonance imaging nationallicence NMDA : N-methyl-d-aspartate nationallicence RAGE : Receptor for advanced glycation end products nationallicence SAH : S-adenosyl-l-homocysteine nationallicence WHO : World Health Organization nationallicence Wedekind Dirk Department of Psychiatry and Psychotherapy, University of Goettingen, von-Siebold-Strasse 5, 37075, Goettingen, Germany aut Neumann Karolin Department of Psychiatry and Psychotherapy, University of Goettingen, von-Siebold-Strasse 5, 37075, Goettingen, Germany aut Falkai Peter Department of Psychiatry and Psychotherapy, University of Goettingen, von-Siebold-Strasse 5, 37075, Goettingen, Germany aut Malchow Berend Department of Psychiatry and Psychotherapy, University of Goettingen, von-Siebold-Strasse 5, 37075, Goettingen, Germany aut Engel Kirsten Department of Psychiatry and Psychotherapy, University of Goettingen, von-Siebold-Strasse 5, 37075, Goettingen, Germany aut Jamrozinski Katja Department of Psychosomatic Medicine and Psychotherapy, University of Goettingen, von-Siebold-Strasse 5, 37075, Goettingen, Germany aut Havemann-Reinecke Ursula Department of Psychiatry and Psychotherapy, University of Goettingen, von-Siebold-Strasse 5, 37075, Goettingen, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/2(2011-03-01), 133-138 0940-1334 261:2<133 2011 261 406 https://doi.org/10.1007/s00406-010-0121-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0121-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wedekind Dirk Department of Psychiatry and Psychotherapy, University of Goettingen, von-Siebold-Strasse 5, 37075, Goettingen, Germany aut NATIONALLICENCE 700 1- Neumann Karolin Department of Psychiatry and Psychotherapy, University of Goettingen, von-Siebold-Strasse 5, 37075, Goettingen, Germany aut NATIONALLICENCE 700 1- Falkai Peter Department of Psychiatry and Psychotherapy, University of Goettingen, von-Siebold-Strasse 5, 37075, Goettingen, Germany aut NATIONALLICENCE 700 1- Malchow Berend Department of Psychiatry and Psychotherapy, University of Goettingen, von-Siebold-Strasse 5, 37075, Goettingen, Germany aut NATIONALLICENCE 700 1- Engel Kirsten Department of Psychiatry and Psychotherapy, University of Goettingen, von-Siebold-Strasse 5, 37075, Goettingen, Germany aut NATIONALLICENCE 700 1- Jamrozinski Katja Department of Psychosomatic Medicine and Psychotherapy, University of Goettingen, von-Siebold-Strasse 5, 37075, Goettingen, Germany aut NATIONALLICENCE 700 1- Havemann-Reinecke Ursula Department of Psychiatry and Psychotherapy, University of Goettingen, von-Siebold-Strasse 5, 37075, Goettingen, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/2(2011-03-01), 133-138 0940-1334 261:2<133 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer