caa a22 4500 445344628 CHVBK 20180317142825.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00406-010-0126-x doi (NATIONALLICENCE)springer-10.1007/s00406-010-0126-x Is 5-HTTLPR linked to the response of selective serotonin reuptake inhibitors in MDD? [Elektronische Daten] [Ari Illi, Outi Poutanen, Eija Setälä-Soikkeli, Olli Kampman, Merja Viikki, Heini Huhtala, Nina Mononen, Susann Haraldsson, Pasi Koivisto, Esa Leinonen, Terho Lehtimäki] The role of a functional polymorphism in the transcriptional control region of serotonin transporter gene (5-HTTLPR, SERTPR) has been studied intensively in major depression and in the response to selective serotonin inhibitors (SSRIs) in major depression. The findings have been contradictory, although majority of the studies indicate that the short allele is associated with poor response to SSRIs in major depression. In the present study, we evaluated the association of 5-HTTLPR with treatment response to SSRI medication in Finnish Caucasian MDD patients. A secondary purpose was to study the possible association of this particular polymorphism with major depressive disorder. The aim of the study was to replicate the previous findings in this area. Primary outcomes of the treatment were remission, defined by an exit score of seven or less, and response, defined by a reduction of at least 50% on the MADRS. We had also a control population of 375 healthy blood donors, as a secondary objective was to evaluate the possible association of this particular polymorphism with major depressive disorder. Twenty-nine of the 85 (34.1%) patients reached the remission and 58.8% achieved the predefined response criteria. The l/l genotype of 5-HTTLPR was presented in 51.7% of those patients who achieved remission vs. 25.0% in the non-remitters (P=0.03). The result remained statistically significant after adjusting for age, gender, medication and MADRS points at the study entry. However, the small sample size limits the reliability of this result. Springer-Verlag, 2010 Serotonin transporter nationallicence 5-HTTLPR nationallicence MDD nationallicence SSRI nationallicence Drug response nationallicence Illi Ari Medical School, University of Tampere, 33014, Tampere, Finland aut Poutanen Outi Department of Psychiatry, Tampere University Hospital, Tampere, Finland aut Setälä-Soikkeli Eija Department of Psychiatry, Kanta-Häme Central Hospital, Hämeenlinna, Finland aut Kampman Olli Medical School, University of Tampere, 33014, Tampere, Finland aut Viikki Merja Medical School, University of Tampere, 33014, Tampere, Finland aut Huhtala Heini School of Public Health, University of Tampere, Tampere, Finland aut Mononen Nina Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland aut Haraldsson Susann Division of Medical and Clinical Genetics, Department of Medical Biosciences, Umeå University, Umeå, Sweden aut Koivisto Pasi Division of Medical and Clinical Genetics, Department of Medical Biosciences, Umeå University, Umeå, Sweden aut Leinonen Esa Medical School, University of Tampere, 33014, Tampere, Finland aut Lehtimäki Terho Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/2(2011-03-01), 95-102 0940-1334 261:2<95 2011 261 406 https://doi.org/10.1007/s00406-010-0126-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0126-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Illi Ari Medical School, University of Tampere, 33014, Tampere, Finland aut NATIONALLICENCE 700 1- Poutanen Outi Department of Psychiatry, Tampere University Hospital, Tampere, Finland aut NATIONALLICENCE 700 1- Setälä-Soikkeli Eija Department of Psychiatry, Kanta-Häme Central Hospital, Hämeenlinna, Finland aut NATIONALLICENCE 700 1- Kampman Olli Medical School, University of Tampere, 33014, Tampere, Finland aut NATIONALLICENCE 700 1- Viikki Merja Medical School, University of Tampere, 33014, Tampere, Finland aut NATIONALLICENCE 700 1- Huhtala Heini School of Public Health, University of Tampere, Tampere, Finland aut NATIONALLICENCE 700 1- Mononen Nina Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland aut NATIONALLICENCE 700 1- Haraldsson Susann Division of Medical and Clinical Genetics, Department of Medical Biosciences, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Koivisto Pasi Division of Medical and Clinical Genetics, Department of Medical Biosciences, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Leinonen Esa Medical School, University of Tampere, 33014, Tampere, Finland aut NATIONALLICENCE 700 1- Lehtimäki Terho Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/2(2011-03-01), 95-102 0940-1334 261:2<95 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer