caa a22 4500 445347805 CHVBK 20180317142834.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00056-011-0034-3 doi (NATIONALLICENCE)springer-10.1007/s00056-011-0034-3 Effect of vitaminC on bone formation in the expanded inter-premaxillary suture. Early bone changes [Elektronische Daten] [T. Uysal, M. Amasyali, H. Olmez, S. Enhos, Y. Karslioglu, O. Gunhan] Effekt von VitaminC auf die Knochenbildung in der expandierten Gaumennaht. Frühe Knochenstrukturveränderungen Aim: The aim of this experimental study was to histomorphometrically evaluate the effects of vitaminC administration on bone formation in response to expansion of the rat inter-premaxillary suture. Materials and methods: A total of 30 50- to 60-day old Wistar male rats were divided into three groups of equal number. The inter-premaxillary suture in each animal was expanded with a 0.49N force applied to the upper incisors. At 24h after appliance placement, control animals received saline solution (groupI) and two groups were given a single dose of vitaminC using two different methods [locally into the suture (groupII) and systemically via intramuscular injection (groupIII)]. The area of new bone (µm2), the perimeter around the new bone (µm), Feret's diameter (µm), and the percentage of new bone to non-ossified tissue (%) were measured and compared. Kruskal-Wallis and Tukey tests were used for statistical evaluation at the p<0.05 level. Results: We observed significant differences among the groups in all histomorphometric parameters. New bone area, bone perimeter, Feret's diameter, and percentage of new bone dimensions were significantly higher in groupIII than the others (p<0.001). Histomorphometric measurements of bone architecture revealed that this improved in the group administered with vitaminC systemically, while local injection revealed significantly less bone growth than the control group. Conclusion: The systemic administration of vitaminC during the early stages of inter-premaxillary suture expansion may stimulate bone growth. However, local injection of this antioxidant into an orthopedically-expanded suture area has negative effects on bone formation. Urban &amp; Vogel, Muenchen, 2011 VitaminC nationallicence Maxillary expansion nationallicence Image analysis nationallicence Rats nationallicence VitaminC nationallicence Oberkieferexpansion nationallicence Bildanalyse nationallicence Ratten nationallicence Uysal T. Department of Orthodontics, Faculty of Dentistry, Izmir Katip Celebi University, Ortodonti A.D., Cigli, Izmir, Turkey aut Amasyali M. Department of Orthodontics, Center of Dental Sciences, Gülhane Military Medical Academy, Ankara, Turkey aut Olmez H. Department of Orthodontics, Center of Dental Sciences, Gülhane Military Medical Academy, Ankara, Turkey aut Enhos S. Department of Periodontics, Faculty of Dentistry, Erciyes University, Kayseri, Turkey aut Karslioglu Y. Department of Pathology, Faculty of Medicine, Gülhane Military Medical Academy, Ankara, Turkey aut Gunhan O. Department of Pathology, Faculty of Medicine, Gülhane Military Medical Academy, Ankara, Turkey aut Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie Springer-Verlag 72/4(2011-08-01), 290-300 1434-5293 72:4<290 2011 72 56 https://doi.org/10.1007/s00056-011-0034-3 text/html Onlinezugriff via DOI 1 article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00056-011-0034-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Uysal T. Department of Orthodontics, Faculty of Dentistry, Izmir Katip Celebi University, Ortodonti A.D., Cigli, Izmir, Turkey aut NATIONALLICENCE 700 1- Amasyali M. Department of Orthodontics, Center of Dental Sciences, Gülhane Military Medical Academy, Ankara, Turkey aut NATIONALLICENCE 700 1- Olmez H. Department of Orthodontics, Center of Dental Sciences, Gülhane Military Medical Academy, Ankara, Turkey aut NATIONALLICENCE 700 1- Enhos S. Department of Periodontics, Faculty of Dentistry, Erciyes University, Kayseri, Turkey aut NATIONALLICENCE 700 1- Karslioglu Y. Department of Pathology, Faculty of Medicine, Gülhane Military Medical Academy, Ankara, Turkey aut NATIONALLICENCE 700 1- Gunhan O. Department of Pathology, Faculty of Medicine, Gülhane Military Medical Academy, Ankara, Turkey aut NATIONALLICENCE 773 0- Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie Springer-Verlag 72/4(2011-08-01), 290-300 1434-5293 72:4<290 2011 72 56 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer