caa a22 4500 445350369 CHVBK 20180317142842.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00221-011-2745-5 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2745-5 The interplay of cue modality and response latency in brain areas supporting crossmodal motor preparation: an event-related fMRI study [Elektronische Daten] [Zainab Fatima, Anthony McIntosh] Crossmodal (auditory, visual) motor facilitation can be defined as a cue in one sensory modality eliciting speeded responses to targets in a different sensory modality. We used event-related functional magnetic resonance imaging (fMRI) to isolate brain activity underlying crossmodal motor preparation. Our predictions were that interactions between input modality and processes underlying response selection would be indexed by distinct spatiotemporal brain dynamics. A crossmodal response selection task was designed in which a central, nonspatial cue indicated the response rule (compatible or incompatible) to a lateralized target. Cues and targets appeared in auditory and visual modalities and were separated by a lengthy delay period in which cue-related brain activity could be dissociated. We found faster reaction times to auditory compared with visual cues. Next, we correlated brain activity with behavioural performance using multivariate spatiotemporal partial least squares. We identified a distinct, significant brain-behaviour pattern in which faster reaction times to auditory cues were correlated with higher blood oxygenation level-dependent percent signal change in medial visual, frontoparietal (inferior parietal lobule, superior frontal gyrus and premotor cortex) and subcortical (thalamus and cerebellum) areas. For visual cues, quicker responses were linked to greater activity in the same frontoparietal and subcortical but not medial visual areas. Our results show that both modality-dependent and modality-independent brain areas with different brain-behaviour relationships are implicated in crossmodal motor preparation. Springer-Verlag, 2011 Response compatibility nationallicence Auditory nationallicence Visual nationallicence Partial least squares nationallicence Brain-behaviour correlations nationallicence fMRI nationallicence Fatima Zainab Rotman Research Institute, Baycrest Centre, 3560 Bathurst St, M6A 2E1, Toronto, ON, Canada aut McIntosh Anthony Rotman Research Institute, Baycrest Centre, 3560 Bathurst St, M6A 2E1, Toronto, ON, Canada aut Experimental Brain Research Springer-Verlag 214/1(2011-09-01), 9-17 0014-4819 214:1<9 2011 214 221 https://doi.org/10.1007/s00221-011-2745-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2745-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fatima Zainab Rotman Research Institute, Baycrest Centre, 3560 Bathurst St, M6A 2E1, Toronto, ON, Canada aut NATIONALLICENCE 700 1- McIntosh Anthony Rotman Research Institute, Baycrest Centre, 3560 Bathurst St, M6A 2E1, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 214/1(2011-09-01), 9-17 0014-4819 214:1<9 2011 214 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer