caa a22 4500 445350431 CHVBK 20180317142842.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00221-011-2844-3 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2844-3 Potentiation of spontaneous and evoked cortical electrical activity after spreading depression: in vivo analysis in well-nourished and malnourished rats [Elektronische Daten] [Thays de Souza, Mariana e Silva, André Gomes, Hélio de Oliveira, Renato Moraes, Catão de Freitas Barbosa, Rubem Guedes] Cortical spreading depression (CSD) is influenced by brain excitability and is related to neurological diseases, such as epilepsy. In vitro evidence indicates that neuronal electrical activity is potentiated after CSD. Malnutrition can cause electrophysiological changes in the brain, both in animals and in humans. Here, we investigated in vivo whether CSD potentiates the amplitude of electrocorticogram (ECoG) and of transcallosal evoked responses in adult well-nourished (W), early-malnourished (M), and food-restricted rats. ECoG amplitudes were compared before and after CSD, at two parietal regions (designated the anterior and posterior regions). In the anterior region, post-CSD amplitudes of the ECoG waves were 13-23% higher (P<0.05) than the pre-CSD values in all groups. In the posterior region, amplitudes increased 22% in the M group only (P<0.05). In a fourth CSD-free group, ECoG amplitude did not change during the four recording hours. Transcallosal electrically evoked cortical responses also increased 21.5±9.6% and 41.8±28.5%, after CSD, in the W and M conditions, respectively, as compared to pre-CSD values. The data support the hypothesis of an in vivo CSD potentiation on cortical excitability as recorded by spontaneous and evoked electrical activity and modulation by nutritional status. Springer-Verlag, 2011 Brain excitability nationallicence Cerebral cortex nationallicence EEG nationallicence Rat nationallicence Transcallosal responses nationallicence de Souza Thays Departamento de Nutrição, Universidade Federal de Pernambuco, 50670901, Recife, Pernambuco, Brazil aut e Silva Mariana Departamento de Nutrição, Universidade Federal de Pernambuco, 50670901, Recife, Pernambuco, Brazil aut Gomes André Departamento de Eletrônica e Sistemas, Universidade Federal Pernambuco, 50711970, Recife, Pernambuco, Brazil aut de Oliveira Hélio Departamento de Eletrônica e Sistemas, Universidade Federal Pernambuco, 50711970, Recife, Pernambuco, Brazil aut Moraes Renato Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brazil aut de Freitas Barbosa Catão Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brazil aut Guedes Rubem Departamento de Nutrição, Universidade Federal de Pernambuco, 50670901, Recife, Pernambuco, Brazil aut Experimental Brain Research Springer-Verlag 214/3(2011-10-01), 463-469 0014-4819 214:3<463 2011 214 221 https://doi.org/10.1007/s00221-011-2844-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2844-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Souza Thays Departamento de Nutrição, Universidade Federal de Pernambuco, 50670901, Recife, Pernambuco, Brazil aut NATIONALLICENCE 700 1- e Silva Mariana Departamento de Nutrição, Universidade Federal de Pernambuco, 50670901, Recife, Pernambuco, Brazil aut NATIONALLICENCE 700 1- Gomes André Departamento de Eletrônica e Sistemas, Universidade Federal Pernambuco, 50711970, Recife, Pernambuco, Brazil aut NATIONALLICENCE 700 1- de Oliveira Hélio Departamento de Eletrônica e Sistemas, Universidade Federal Pernambuco, 50711970, Recife, Pernambuco, Brazil aut NATIONALLICENCE 700 1- Moraes Renato Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brazil aut NATIONALLICENCE 700 1- de Freitas Barbosa Catão Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brazil aut NATIONALLICENCE 700 1- Guedes Rubem Departamento de Nutrição, Universidade Federal de Pernambuco, 50670901, Recife, Pernambuco, Brazil aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 214/3(2011-10-01), 463-469 0014-4819 214:3<463 2011 214 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer