caa a22 4500 445350490 CHVBK 20180317142842.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00221-011-2834-5 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2834-5 Costa Alberto Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Colorado Denver School of Medicine, 12700 East 19th Avenue, Campus Box C-237, 80045, Aurora, CO, USA aut An assessment of optokinetic nystagmus (OKN) in persons with down syndrome [Elektronische Daten] [Alberto Costa] Down syndrome (DS), the most common genetically defined cause of intellectual disability, is the phenotypic consequence of a supernumerary chromosome 21. Persons with DS commonly display deficits in visuomotor integration, motor coordination, and balance. Despite the key roles of the optokinetic and vestibular systems in these submodalities of motor function, a systematic investigation of the optokinetic nystagmus (OKN) and vestibulo-ocular reflex (VOR) in persons with DS had lacked in the literature. Accordingly, this study generated quantitative data on oculomotor function in persons with DS under optokinetic and sinusoidal smooth pursuit stimulation. Thirty-two participants with DS (14-36years old, equally divided by gender) and 32 chronological age- and gender-matched typically developing controls were recruited from the community. Eye movements were recorded by binocular video oculography and an LCD projector produced visual stimulation. Assessments of the gain and frequency of slow phase of OKN beats and number and mean amplitude of intruding saccades during smooth pursuit were performed. Individuals with DS displayed angular velocity-dependent reduction in OKN gain and number of produced nystagmus beats compared to controls. The gain of the smooth pursuit was not significantly different between participants with DS and control participants. However, the number and mean amplitude of intruding saccades during smooth pursuit were increased in participants with DS compared to control participants. These findings may have implications to the understanding of the neurological basis of the motor dysfunction that affects performance in many practical tasks persons with DS encounter in their everyday lives. Springer-Verlag, 2011 Down syndrome nationallicence Trisomy 21 nationallicence Vestibulo-ocular reflex nationallicence Optokinetic nystagmus nationallicence Balance nationallicence Postural control nationallicence Experimental Brain Research Springer-Verlag 214/3(2011-10-01), 381-391 0014-4819 214:3<381 2011 214 221 https://doi.org/10.1007/s00221-011-2834-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2834-5 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Costa Alberto Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Colorado Denver School of Medicine, 12700 East 19th Avenue, Campus Box C-237, 80045, Aurora, CO, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 214/3(2011-10-01), 381-391 0014-4819 214:3<381 2011 214 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer