caa a22 4500 445350512 CHVBK 20180317142842.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00221-011-2841-6 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2841-6 Spatial and nonspatial implicit motor learning in Korsakoff's amnesia: evidence for selective deficits [Elektronische Daten] [Ilse Van Tilborg, Roy Kessels, Pauline Kruijt, Arie Wester, Wouter Hulstijn] Patients with amnesia have deficits in declarative memory but intact memory for motor and perceptual skills, which suggests that explicit memory and implicit memory are distinct. However, the evidence that implicit motor learning is intact in amnesic patients is contradictory. This study investigated implicit sequence learning in amnesic patients with Korsakoff's syndrome (N=20) and matched controls (N=14), using the classical Serial Reaction Time Task and a newly developed Pattern Learning Task in which the planning and execution of the responses are more spatially demanding. Results showed that implicit motor learning occurred in both groups of participants; however, on the Pattern Learning Task, the percentage of errors did not increase in the Korsakoff group in the random test phase, which is indicative of less implicit learning. Thus, our findings show that the performance of patients with Korsakoff's syndrome is compromised on an implicit learning task with a strong spatial response component. The Author(s), 2011 Korsakoff's syndrome nationallicence Amnesia nationallicence Implicit learning nationallicence Motor learning nationallicence Sequence learning nationallicence Memory nationallicence Van Tilborg Ilse Department of Medical Psychology, ZGT Hospital, PO Box 7600, 7600 SZ, Almelo, The Netherlands aut Kessels Roy Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands aut Kruijt Pauline Sarr Centre for Autism, Parnassia Bavo Psychiatric Institute, Rotterdam, The Netherlands aut Wester Arie Korsakoff Clinic, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands aut Hulstijn Wouter Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands aut Experimental Brain Research Springer-Verlag 214/3(2011-10-01), 427-435 0014-4819 214:3<427 2011 214 221 https://doi.org/10.1007/s00221-011-2841-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2841-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Van Tilborg Ilse Department of Medical Psychology, ZGT Hospital, PO Box 7600, 7600 SZ, Almelo, The Netherlands aut NATIONALLICENCE 700 1- Kessels Roy Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Kruijt Pauline Sarr Centre for Autism, Parnassia Bavo Psychiatric Institute, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Wester Arie Korsakoff Clinic, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands aut NATIONALLICENCE 700 1- Hulstijn Wouter Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 214/3(2011-10-01), 427-435 0014-4819 214:3<427 2011 214 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer