caa a22 4500 445350601 CHVBK 20180317142842.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00221-011-2849-y doi (NATIONALLICENCE)springer-10.1007/s00221-011-2849-y The role of VEGF/VEGFR2 signaling in peripheral stimulation-induced cerebral neurovascular regeneration after ischemic stroke in mice [Elektronische Daten] [Wen-Lei Li, Jamie Fraser, Shan Yu, Jian Zhu, Ya-Jun Jiang, Ling Wei] Ischemic stroke is a major cause of mortality and morbidity worldwide but effective treatments are limited. Strategies to enhance neurovascular remodeling following stroke provide promising opportunities to improve tissue repair and functional recovery. We have previously demonstrated that whisker activity promotes central angiogenesis in rodent models of whisker-barrel cortex stroke. However, the mechanisms involved in the regulation of neurovascular plasticity by peripheral stimulation are not well-defined. Here, we report that angiogenesis and neurogenesis occur concurrently after cerebral ischemia and whisker stimulation in mice. We show that neuroblasts expressing vascular endothelial growth factor receptor 2 (VEGFR2) migrate along the vessels. Blocking VEGFR2 with the selective inhibitor SU5416 (semaxinib) attenuates ischemia-induced regenerative responses and completely prevents whisker stimulation-induced neurovascular remodeling. These results suggest that VEGFR2-mediated signaling plays an important role in promoting post-ischemia neurovascular remodeling and provides a link between angiogenesis and neurogenesis. Springer-Verlag, 2011 Cerebral ischemia nationallicence Whisker stimulation nationallicence Neurovascular unit nationallicence VEGF/VEGFR2 signaling nationallicence Semaxinib nationallicence Li Wen-Lei Department of Neurology, Jiangsu Province Hospital of Traditional Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, 210029, Nanjing, China aut Fraser Jamie Department of Pathology, Medical University of South Carolina, 29425, Charleston, SC, USA aut Yu Shan Department of Anesthesiology, Emory University School of Medicine, 30322, Atlanta, GA, USA aut Zhu Jian Department of Endocrinology, Nanjing Medical University Affiliated Nanjing First Hospital, 210012, Nanjing, China aut Jiang Ya-Jun Department of Neurology, Jiangsu Province Hospital of Traditional Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, 210029, Nanjing, China aut Wei Ling Department of Anesthesiology, Emory University School of Medicine, 30322, Atlanta, GA, USA aut Experimental Brain Research Springer-Verlag 214/4(2011-10-01), 503-513 0014-4819 214:4<503 2011 214 221 https://doi.org/10.1007/s00221-011-2849-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2849-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Wen-Lei Department of Neurology, Jiangsu Province Hospital of Traditional Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, 210029, Nanjing, China aut NATIONALLICENCE 700 1- Fraser Jamie Department of Pathology, Medical University of South Carolina, 29425, Charleston, SC, USA aut NATIONALLICENCE 700 1- Yu Shan Department of Anesthesiology, Emory University School of Medicine, 30322, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Zhu Jian Department of Endocrinology, Nanjing Medical University Affiliated Nanjing First Hospital, 210012, Nanjing, China aut NATIONALLICENCE 700 1- Jiang Ya-Jun Department of Neurology, Jiangsu Province Hospital of Traditional Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, 210029, Nanjing, China aut NATIONALLICENCE 700 1- Wei Ling Department of Anesthesiology, Emory University School of Medicine, 30322, Atlanta, GA, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 214/4(2011-10-01), 503-513 0014-4819 214:4<503 2011 214 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer