caa a22 4500 445350652 CHVBK 20180317142843.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00221-011-2853-2 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2853-2 Mechanism of functional recovery after repetitive transcranial magnetic stimulation (rTMS) in the subacute cerebral ischemic rat model: neural plasticity or anti-apoptosis? [Elektronische Daten] [Kyung Yoon, Yong-Taek Lee, Tai Han] Repetitive transcranial magnetic stimulation (rTMS) has been studied increasingly in recent years to determine whether it has a therapeutic benefit on recovery after stroke. However, the underlying mechanisms of rTMS in stroke recovery remain unclear. Here, we evaluated the effect of rTMS on functional recovery and its underlying mechanism by assessing proteins associated with neural plasticity and anti-apoptosis in the peri-lesional area using a subacute cerebral ischemic rat model. Twenty cerebral ischemic rats were randomly assigned to the rTMS or the sham group at post-op day 4. A total of 3,500 impulses with 10Hz frequency were applied to ipsilesional cortex over a 2-week period. Functional outcome was measured before (post-op day 4) and after rTMS (post-op day 18). The rTMS group showed more functional improvement on the beam balance test and had stronger Bcl-2 and weaker Bax expression on immunohistochemistry compared with the sham group. The expression of NMDA and MAP-2 showed no significant difference between the two groups. These results suggest that rTMS in subacute cerebral ischemia has a therapeutic effect on functional recovery and is associated with an anti-apoptotic mechanism in the peri-ischemic area rather than with neural plasticity. Springer-Verlag, 2011 Repetitive transcranial magnetic stimulation nationallicence Cerebral Ischemia nationallicence Plasticity nationallicence Apoptosis nationallicence Peri-ischemic nationallicence Yoon Kyung Department of Rehabilitation Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, #108, Pyung-dong, 110-746, Jongno-gu, Seoul, South Korea aut Lee Yong-Taek Department of Rehabilitation Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, #108, Pyung-dong, 110-746, Jongno-gu, Seoul, South Korea aut Han Tai Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul, South Korea aut Experimental Brain Research Springer-Verlag 214/4(2011-10-01), 549-556 0014-4819 214:4<549 2011 214 221 https://doi.org/10.1007/s00221-011-2853-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2853-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoon Kyung Department of Rehabilitation Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, #108, Pyung-dong, 110-746, Jongno-gu, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Yong-Taek Department of Rehabilitation Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, #108, Pyung-dong, 110-746, Jongno-gu, Seoul, South Korea aut NATIONALLICENCE 700 1- Han Tai Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul, South Korea aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 214/4(2011-10-01), 549-556 0014-4819 214:4<549 2011 214 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer