caa a22 4500 445350717 CHVBK 20180317142843.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00221-011-2829-2 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2829-2 Short-interval intracortical inhibition in Parkinson's disease using anterior-posterior directed currents [Elektronische Daten] [R. Hanajima, Y. Terao, Y. Shirota, S. Ohminami, S. Nakatani-Enomoto, S. Okabe, H. Matsumoto, R. Tsutsumi, Y. Ugawa] Reduced short-interval intracortical inhibition (SICI) is reported in Parkinson's disease (PD) and is considered to reflect abnormal GABAergic inhibitory system of the primary motor cortex in PD. We have recently shown, however, that SICI using anterior-posterior directed currents in the brain was normal in focal dystonia even though that using posterior-anterior currents was abnormal, indicating that the GABAergic system of the primary motor cortex is largely normal in dystonia. Here, we studied SICI in PD to clarify whether the GABAergic system is completely impaired in PD. We used paired-pulse transcranial magnetic stimulation to study SICI at interstimulus intervals of 3 and 4ms with anterior-posterior or posterior-anterior directed currents in eight PD patients and ten healthy volunteers. The amount of SICI with posterior-anterior directed currents was reduced in PD patients compared with healthy volunteers; in contrast, SICI studied with anterior-posterior directed currents was normal in PD patients. These observations may be due to the difference in I-wave composition generated by the two directed currents and/or the difference in responsible inhibitory interneurons for the inhibition between the two current directions. We suggest that some or a part of inhibitory interneurons are not involved in PD. This discrepancy between SICI using posterior-anterior and anterior-posterior directed currents experiments may provide additional information about the circuits of the motor cortex. Springer-Verlag, 2011 Transcranial magnetic stimulation nationallicence GABAergic inhibition nationallicence I-waves nationallicence Parkinson disease nationallicence Short-interval intracortical inhibition nationallicence Hanajima R. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut Terao Y. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut Shirota Y. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut Ohminami S. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut Nakatani-Enomoto S. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut Okabe S. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut Matsumoto H. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut Tsutsumi R. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut Ugawa Y. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut Experimental Brain Research Springer-Verlag 214/2(2011-10-01), 317-321 0014-4819 214:2<317 2011 214 221 https://doi.org/10.1007/s00221-011-2829-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2829-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hanajima R. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Terao Y. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Shirota Y. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Ohminami S. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakatani-Enomoto S. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Okabe S. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Matsumoto H. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Tsutsumi R. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Ugawa Y. Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 214/2(2011-10-01), 317-321 0014-4819 214:2<317 2011 214 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer