caa a22 4500 445350733 CHVBK 20180317142843.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00221-011-2826-5 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2826-5 The origins of neuromuscular fatigue post-stroke [Elektronische Daten] [S. Knorr, T. Ivanova, T. Doherty, J. Campbell, S. Garland] Fatigue post-stroke is a disabling and persistent symptom affecting many stroke survivors. Despite its high prevalence, the pathophysiology underlying this phenomenon remains obscure. The aim of the present study was to investigate the origins of neuromuscular fatigue post-stroke. Ten chronic stroke survivors and 10 controls sustained an isometric contraction at 30% of maximal voluntary contraction (MVC) with the ankle dorsiflexors. Motor evoked potential (MEP), cortical silent period (SP), voluntary activation, M wave and contractile properties were evaluated before, during and after fatigue among the paretic, non-paretic and control limbs. The pattern of response to fatigue in the non-paretic and control limbs was comparable; therefore, results are presented between the paretic and non-paretic limbs. Before fatigue, reduced MVC peak torque and MEP amplitude were observed on the paretic side in comparison with the non-paretic side. During fatigue, the cortical SP duration increased significantly in both limbs, whereas the MEP amplitude significantly increased only in the non-paretic limb. After fatigue, MVC peak torque decreased significantly in both limbs. Significant reductions in M wave and twitch peak torque were observed in both limbs, pointing to the development of peripheral fatigue. However, central fatigue, evident by a significant reduction in voluntary activation, was greater in the paretic than in the non-paretic limb. After stroke, an inability to increase central excitability in response to an increased cortical inhibition associated with the fatiguing contraction may contribute to central fatigue observed in the paretic limb, which may also be linked to increased self-reported fatigue during activities of daily living. These findings advance our understanding of the neuromuscular basis of fatigue post-stroke. Springer-Verlag, 2011 Stroke nationallicence Transcranial magnetic stimulation nationallicence Motor evoked potential nationallicence Cortical silent period nationallicence Voluntary activation nationallicence Neuromuscular fatigue nationallicence Knorr S. Graduate Program in Health and Rehabilitation Sciences, University of Western Ontario, N6G 1H1, London, ON, Canada aut Ivanova T. Department of Physical Therapy, University of British Columbia, 212-2177 Wesbrook Mall, V6T 1Z3, Vancouver, BC, Canada aut Doherty T. Department of Clinical Neurological Sciences, University of Western Ontario, N6A 5A5, London, ON, Canada aut Campbell J. School of Kinesiology, University of Western Ontario, N6A 3K7, London, ON, Canada aut Garland S. Department of Physical Therapy, University of British Columbia, 212-2177 Wesbrook Mall, V6T 1Z3, Vancouver, BC, Canada aut Experimental Brain Research Springer-Verlag 214/2(2011-10-01), 303-315 0014-4819 214:2<303 2011 214 221 https://doi.org/10.1007/s00221-011-2826-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2826-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Knorr S. Graduate Program in Health and Rehabilitation Sciences, University of Western Ontario, N6G 1H1, London, ON, Canada aut NATIONALLICENCE 700 1- Ivanova T. Department of Physical Therapy, University of British Columbia, 212-2177 Wesbrook Mall, V6T 1Z3, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- Doherty T. Department of Clinical Neurological Sciences, University of Western Ontario, N6A 5A5, London, ON, Canada aut NATIONALLICENCE 700 1- Campbell J. School of Kinesiology, University of Western Ontario, N6A 3K7, London, ON, Canada aut NATIONALLICENCE 700 1- Garland S. Department of Physical Therapy, University of British Columbia, 212-2177 Wesbrook Mall, V6T 1Z3, Vancouver, BC, Canada aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 214/2(2011-10-01), 303-315 0014-4819 214:2<303 2011 214 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer