caa a22 4500 445350741 CHVBK 20180317142843.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00221-011-2832-7 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2832-7 Correlation between olfactory bulb volume and olfactory function in children and adolescents [Elektronische Daten] [T. Hummel, M. Smitka, S. Puschmann, J. Gerber, B. Schaal, D. Buschhüter] The olfactory bulb (OB) is considered to be the most important relay station in odor processing. The present study aimed to investigate the volumetric development of the human bulb and the olfactory function during childhood and youth. Furthermore, the present study aimed to investigate a possible correlation between OB volume and specific olfactory functions including odor threshold, odor discrimination and odor identification. A total of 87 subjects (46 boys, 41 girls), aged 1-17years (mean age 8years), participated in this study. None of them reported olfactory dysfunction or had signs of a dysfunctional sense of smell. Whenever possible, participants received a volumetric scan of the brain and lateralized olfactory tests. Volumetric measurements of the right and left OB were taken by manual segmentation of the coronal slices through the OB. Significant correlations between OB volumes and olfactory function were observed. Both, OB volumes and olfactory function increased with age, although the correlation between structure and function was not mediated by the subjects' age. In conclusion, for the first time, the present study showed a correlation between OB volume and olfactory functions in children. Springer-Verlag, 2011 Brain nationallicence Olfaction nationallicence Smell nationallicence Olfactory bulb nationallicence Children nationallicence MRI nationallicence Volumetry nationallicence Plasticity nationallicence Development nationallicence Hummel T. Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany aut Smitka M. Department of Pediatrics, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany aut Puschmann S. Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany aut Gerber J. Department of Neuroradiology, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany aut Schaal B. Centre de Gout, Dijon, France aut Buschhüter D. Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany aut Experimental Brain Research Springer-Verlag 214/2(2011-10-01), 285-291 0014-4819 214:2<285 2011 214 221 https://doi.org/10.1007/s00221-011-2832-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2832-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hummel T. Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Smitka M. Department of Pediatrics, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Puschmann S. Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Gerber J. Department of Neuroradiology, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Schaal B. Centre de Gout, Dijon, France aut NATIONALLICENCE 700 1- Buschhüter D. Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 214/2(2011-10-01), 285-291 0014-4819 214:2<285 2011 214 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer