caa a22 4500 445350806 CHVBK 20180317142843.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00221-011-2825-6 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2825-6 Neuronal activity in medial superior temporal area (MST) during memory-based smooth pursuit eye movements in monkeys [Elektronische Daten] [Sergei Kurkin, Teppei Akao, Natsuko Shichinohe, Junko Fukushima, Kikuro Fukushima] We examined recently neuronal substrates for predictive pursuit using a memory-based smooth pursuit task that distinguishes the discharge related to memory of visual motion-direction from that related to movement preparation. We found that the supplementary eye fields (SEF) contain separate signals coding memory and assessment of visual motion-direction, decision not-to-pursue, and preparation for pursuit. Since medial superior temporal area (MST) is essential for visual motion processing and projects to SEF, we examined whether MST carried similar signals. We analyzed the discharge of 108 MSTd neurons responding to visual motion stimuli. The majority (69/108=64%) were also modulated during smooth pursuit. However, in nearly all (104/108=96%) of the MSTd neurons tested, there was no significant discharge modulation during the delay periods that required memory of visual motion-direction or preparation for smooth pursuit or not-to-pursue. Only 4 neurons of the 108 (4%) exhibited significantly higher discharge rates during the delay periods; however, their responses were non-directional and not instruction specific. Representative signals in the MSTd clearly differed from those in the SEF during memory-based smooth pursuit. MSTd neurons are unlikely to provide signals for memory of visual motion-direction or preparation for smooth pursuit eye movements. The Author(s), 2011 MST nationallicence Visual motion nationallicence Memory nationallicence Movement preparation nationallicence Smooth pursuit nationallicence Monkey nationallicence Kurkin Sergei Department of Physiology, School of Medicine, Hokkaido University, Sapporo, Japan aut Akao Teppei Department of Physiology, School of Medicine, Hokkaido University, Sapporo, Japan aut Shichinohe Natsuko Department of Physiology, School of Medicine, Hokkaido University, Sapporo, Japan aut Fukushima Junko Faculty of Health Sciences, Hokkaido University, Sapporo, Japan aut Fukushima Kikuro Department of Physiology, School of Medicine, Hokkaido University, Sapporo, Japan aut Experimental Brain Research Springer-Verlag 214/2(2011-10-01), 293-301 0014-4819 214:2<293 2011 214 221 https://doi.org/10.1007/s00221-011-2825-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2825-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kurkin Sergei Department of Physiology, School of Medicine, Hokkaido University, Sapporo, Japan aut NATIONALLICENCE 700 1- Akao Teppei Department of Physiology, School of Medicine, Hokkaido University, Sapporo, Japan aut NATIONALLICENCE 700 1- Shichinohe Natsuko Department of Physiology, School of Medicine, Hokkaido University, Sapporo, Japan aut NATIONALLICENCE 700 1- Fukushima Junko Faculty of Health Sciences, Hokkaido University, Sapporo, Japan aut NATIONALLICENCE 700 1- Fukushima Kikuro Department of Physiology, School of Medicine, Hokkaido University, Sapporo, Japan aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 214/2(2011-10-01), 293-301 0014-4819 214:2<293 2011 214 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer