caa a22 4500 445350814 CHVBK 20180317142843.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00221-011-2823-8 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2823-8 Gaze shift duration, independent of amplitude, influences the number of spikes in the burst for medium-lead burst neurons in pontine reticular formation [Elektronische Daten] [Mark Walton, Edward Freedman] Changes in the direction of the line of sight (gaze) allow successive sampling of the visual environment. Saccadic eye movements accomplish this goal when the head does not move. Medium-lead burst neurons (MLBs) in the paramedian pontine reticular formation (PPRF) discharge a high frequency burst of action potentials starting ~12ms before the saccade begins. A subgroup of MLBs rostral of abducens nucleus monosynaptically excites oculomotor neurons. The number of spikes in the presaccadic burst is correlated with the amplitude of the horizontal component of the saccade, and the peak discharge rate is correlated with peak eye velocity. During head-unrestrained gaze shifts, a linear relationship between the number of action potentials in MLB bursts and gaze (but not eye) amplitude has been reported. The anatomical connection of MLBs to motor neurons and the similarity between the phasic motor neuron burst and MLB discharge have raised questions about the usefulness of counting spikes in MLBs to determine their role in eye-head coordination. We investigated this issue using a behavioral technique that permits a dissociation of eye movement amplitude and duration during constant vector gaze shifts. Surprisingly, during gaze shifts of constant amplitude and direction, we observe a nearly linear, positive correlation between saccade duration and spike number associated with a negative correlation between spike number and saccade amplitude. These data constrain models of the oculomotor controller and may further define the time-dependence of hypothesized neural integration in this system. Springer-Verlag, 2011 Gaze nationallicence Saccade nationallicence Primate nationallicence PPRF nationallicence Head unrestrained nationallicence Walton Mark Department of Neurobiology and Anatomy, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Ave., Box 603, 14642, Rochester, NY, USA aut Freedman Edward Department of Neurobiology and Anatomy, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Ave., Box 603, 14642, Rochester, NY, USA aut Experimental Brain Research Springer-Verlag 214/2(2011-10-01), 225-239 0014-4819 214:2<225 2011 214 221 https://doi.org/10.1007/s00221-011-2823-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2823-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Walton Mark Department of Neurobiology and Anatomy, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Ave., Box 603, 14642, Rochester, NY, USA aut NATIONALLICENCE 700 1- Freedman Edward Department of Neurobiology and Anatomy, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Ave., Box 603, 14642, Rochester, NY, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 214/2(2011-10-01), 225-239 0014-4819 214:2<225 2011 214 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer