caa a22 4500 44535089X CHVBK 20180317142843.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00221-011-2558-6 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2558-6 Complementary gain modifications of the cervico-ocular (COR) and angular vestibulo-ocular (aVOR) reflexes after canal plugging [Elektronische Daten] [Sergei Yakushin, Olga Kolesnikova, Bernard Cohen, Dmitri Ogorodnikov, Jun-Ichi Suzuki, Charles Della Santina, Lloyd Minor, Theodore Raphan] To determine whether the COR compensates for the loss of aVOR gain, independent of species, we studied cynomolgus and rhesus monkeys in which all six semicircular canals were plugged. Gains and phases of the aVOR and COR were determined at frequencies ranging from 0.02 to 6Hz and fit with model-based transfer functions. Following canal plugging in a rhesus monkey, the acute stage aVOR gain was small and there were absent responses to thrusts of yaw rotation. In the chronic state, aVOR behavior was characterized by a cupula/endolymph time constant of ≈0.07s, responding only to high frequencies of head rotation. COR gains were ≈0 before surgery but increased to ≈0.15 at low frequencies just after surgery; the COR gains increased to ≈0.4 over the next 12weeks. Nine weeks after surgery, the summated aVOR+COR responses compensated for head velocity in space in the 0.5-3Hz frequency range. The gains and phases continued to improve until the 35th week, where the combined aVOR+COR stabilized with gains of ≈0.5-0.6 and the phases were compensatory over all frequencies. Two cynomolgus monkeys operated 3-12 years earlier had similar frequency characteristics of the aVOR and COR. The combined aVOR+COR gains were ≈0.4-0.8 with compensatory phases. To achieve gains close to 1.0, other mechanisms may contribute to gaze compensation, especially with the head free. Thus, while there are individual variations in the time of adaptation of the gain and phase parameters, the essential functional organization of the adaption to vestibular lesions is uniform across these species. Springer-Verlag, 2011 Cervico-ocular reflex nationallicence Semicircular canal plugging nationallicence Rhesus monkey nationallicence Cynomolgus monkey nationallicence Adaptation nationallicence Angular VOR nationallicence COR nationallicence Yakushin Sergei Department of Neurology, Box 1135, Mount Sinai School of Medicine, 1 East 100th Street, 10029, New York, NY, USA aut Kolesnikova Olga Department of Neurology, Box 1135, Mount Sinai School of Medicine, 1 East 100th Street, 10029, New York, NY, USA aut Cohen Bernard Department of Neurology, Box 1135, Mount Sinai School of Medicine, 1 East 100th Street, 10029, New York, NY, USA aut Ogorodnikov Dmitri Department of Neurology, Box 1135, Mount Sinai School of Medicine, 1 East 100th Street, 10029, New York, NY, USA aut Suzuki Jun-Ichi Department of Otolaryngology, Teikyo University, Tokyo, Japan aut Della Santina Charles Department of Otolaryngology-Head & Neck Surgery, John Hopkins University, Baltimore, MD, USA aut Minor Lloyd Department of Otolaryngology-Head & Neck Surgery, John Hopkins University, Baltimore, MD, USA aut Raphan Theodore Department of Computer and Information Science, Brooklyn College of the City University of New York, Brooklyn, NY, USA aut Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 549-560 0014-4819 210:3-4<549 2011 210 221 https://doi.org/10.1007/s00221-011-2558-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2558-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yakushin Sergei Department of Neurology, Box 1135, Mount Sinai School of Medicine, 1 East 100th Street, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Kolesnikova Olga Department of Neurology, Box 1135, Mount Sinai School of Medicine, 1 East 100th Street, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Cohen Bernard Department of Neurology, Box 1135, Mount Sinai School of Medicine, 1 East 100th Street, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Ogorodnikov Dmitri Department of Neurology, Box 1135, Mount Sinai School of Medicine, 1 East 100th Street, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Suzuki Jun-Ichi Department of Otolaryngology, Teikyo University, Tokyo, Japan aut NATIONALLICENCE 700 1- Della Santina Charles Department of Otolaryngology-Head & Neck Surgery, John Hopkins University, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Minor Lloyd Department of Otolaryngology-Head & Neck Surgery, John Hopkins University, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Raphan Theodore Department of Computer and Information Science, Brooklyn College of the City University of New York, Brooklyn, NY, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 549-560 0014-4819 210:3-4<549 2011 210 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer