caa a22 4500 445350903 CHVBK 20180317142843.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00221-011-2622-2 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2622-2 Unidirectional rotations produce asymmetric changes in horizontal VOR gain before and after unilateral labyrinthectomy in macaques [Elektronische Daten] [Munetaka Ushio, Lloyd Minor, Charles Della Santina, David Lasker] Unilateral vestibular lesions cause marked asymmetry in the horizontal vestibulo-ocular reflex (VOR) during rapid head rotations, with VOR gain being lower for head rotations toward the lesion than for rotations in the opposite direction. Reducing this gain asymmetry by enhancing ipsilesional responses would be an important step toward improving gaze stability following vestibular lesions. To that end, there were two goals in this study. First, we wanted to determine whether we could selectively increase VOR gain in only one rotational direction in normal monkeys by exposing them to a training session comprised of a 3-h series of rotations in only one direction (1,000°/s² acceleration to a plateau of 150°/s for 1s) while they wore 1.7× magnifying spectacles. Second, in monkeys with unilateral vestibular lesions, we designed a paradigm intended to reduce the gain asymmetry by rotating the monkeys toward the side of the lesion in the same way as above but without spectacles. There were three main findings (1) unidirectional rotations with magnifying spectacles result in gain asymmetry in normal monkeys, (2) gain asymmetry is reduced when animals are rotated towards the side of the labyrinthectomy via the ipsilesional rotation paradigm, and (3) repeated training causes lasting reduction in VOR gain asymmetry. Springer-Verlag, 2011 Rehabilitation nationallicence Learning nationallicence Training nationallicence Vestibular nationallicence Adaptation nationallicence Ushio Munetaka Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, Ross Bldg. Suite 710, 720 Rutland Ave., 21205, Baltimore, MD, USA aut Minor Lloyd Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, Ross Bldg. Suite 710, 720 Rutland Ave., 21205, Baltimore, MD, USA aut Della Santina Charles Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, Ross Bldg. Suite 710, 720 Rutland Ave., 21205, Baltimore, MD, USA aut Lasker David Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, Ross Bldg. Suite 710, 720 Rutland Ave., 21205, Baltimore, MD, USA aut Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 651-660 0014-4819 210:3-4<651 2011 210 221 https://doi.org/10.1007/s00221-011-2622-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2622-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ushio Munetaka Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, Ross Bldg. Suite 710, 720 Rutland Ave., 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Minor Lloyd Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, Ross Bldg. Suite 710, 720 Rutland Ave., 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Della Santina Charles Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, Ross Bldg. Suite 710, 720 Rutland Ave., 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Lasker David Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, Ross Bldg. Suite 710, 720 Rutland Ave., 21205, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 651-660 0014-4819 210:3-4<651 2011 210 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer