caa a22 4500 445350938 CHVBK 20180317142843.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00221-011-2599-x doi (NATIONALLICENCE)springer-10.1007/s00221-011-2599-x Virtual labyrinth model of vestibular afferent excitation via implanted electrodes: validation and application to design of a multichannel vestibular prosthesis [Elektronische Daten] [Russell Hayden, Stacia Sawyer, Eric Frey, Susumu Mori, Americo Migliaccio, Charles Della Santina] To facilitate design of a multichannel vestibular prosthesis that can restore sensation to individuals with bilateral loss of vestibular hair cell function, we created a virtual labyrinth model. Model geometry was generated through 3-dimensional (3D) reconstruction of microMRI and microCT scans of normal chinchillas (Chinchilla lanigera) acquired with 30-48μm and 12μm voxels, respectively. Virtual electrodes were positioned based on anatomic landmarks, and the extracellular potential field during a current pulse was computed using finite element methods. Potential fields then served as inputs to stochastic, nonlinear dynamic models for each of 2,415 vestibular afferent axons with spiking dynamics based on a modified Smith and Goldberg model incorporating parameters that varied with fiber location in the neuroepithelium. Action potential propagation was implemented by a well validated model of myelinated fibers. We tested the model by comparing predicted and actual 3D angular vestibulo-ocular reflex (aVOR) axes of eye rotation elicited by prosthetic stimuli. Actual responses were measured using 3D video-oculography. The model was individualized for each animal by placing virtual electrodes based on microCT localization of real electrodes. 3D eye rotation axes were predicted from the relative proportion of model axons excited within each of the three ampullary nerves. Multiple features observed empirically were observed as emergent properties of the model, including effects of active and return electrode position, stimulus amplitude and pulse waveform shape on target fiber recruitment and stimulation selectivity. The modeling procedure is partially automated and can be readily adapted to other species, including humans. Springer-Verlag, 2011 Vestibular nationallicence Prosthesis nationallicence Electrical nationallicence Prosthetic nationallicence Implant nationallicence Labyrinth nationallicence Finite element nationallicence Chinchilla nationallicence Hayden Russell Johns Hopkins Vestibular NeuroEngineering Laboratory, 601 N. Caroline Street, Rm 6253, 21287-0910, Baltimore, MD, USA aut Sawyer Stacia Johns Hopkins Vestibular NeuroEngineering Laboratory, 601 N. Caroline Street, Rm 6253, 21287-0910, Baltimore, MD, USA aut Frey Eric Johns Hopkins Vestibular NeuroEngineering Laboratory, 601 N. Caroline Street, Rm 6253, 21287-0910, Baltimore, MD, USA aut Mori Susumu Johns Hopkins Vestibular NeuroEngineering Laboratory, 601 N. Caroline Street, Rm 6253, 21287-0910, Baltimore, MD, USA aut Migliaccio Americo Johns Hopkins Vestibular NeuroEngineering Laboratory, 601 N. Caroline Street, Rm 6253, 21287-0910, Baltimore, MD, USA aut Della Santina Charles Johns Hopkins Vestibular NeuroEngineering Laboratory, 601 N. Caroline Street, Rm 6253, 21287-0910, Baltimore, MD, USA aut Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 623-640 0014-4819 210:3-4<623 2011 210 221 https://doi.org/10.1007/s00221-011-2599-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2599-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hayden Russell Johns Hopkins Vestibular NeuroEngineering Laboratory, 601 N. Caroline Street, Rm 6253, 21287-0910, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Sawyer Stacia Johns Hopkins Vestibular NeuroEngineering Laboratory, 601 N. Caroline Street, Rm 6253, 21287-0910, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Frey Eric Johns Hopkins Vestibular NeuroEngineering Laboratory, 601 N. Caroline Street, Rm 6253, 21287-0910, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Mori Susumu Johns Hopkins Vestibular NeuroEngineering Laboratory, 601 N. Caroline Street, Rm 6253, 21287-0910, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Migliaccio Americo Johns Hopkins Vestibular NeuroEngineering Laboratory, 601 N. Caroline Street, Rm 6253, 21287-0910, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Della Santina Charles Johns Hopkins Vestibular NeuroEngineering Laboratory, 601 N. Caroline Street, Rm 6253, 21287-0910, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 623-640 0014-4819 210:3-4<623 2011 210 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer