caa a22 4500 445350954 CHVBK 20180317142843.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00221-011-2585-3 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2585-3 Interactions between intrinsic membrane and emerging network properties determine signal processing in central vestibular neurons [Elektronische Daten] [C. Rössert, H. Straka] Head/body motion-related sensory signals are transformed in second-order vestibular neurons (2°VN) into commands for appropriate motor reactions that stabilize gaze and posture during locomotion. In all vertebrates, these neurons form functional subgroups with different membrane properties and response dynamics, compatible with the necessity to process a wide range of motion-related sensory signals. In frog, 2°VN subdivide into two well-defined populations with distinctly different intrinsic membrane properties, discharge dynamics and synaptic response characteristics. Tonic 2°VN form low-pass filters with membrane properties that cause synaptic amplification, whereas phasic 2°VN form band-pass filters that cause shunting of repetitive inputs. The different, yet complementary, filter properties render tonic neurons suitable for integration and phasic neurons for differentiation and event detection. Specific insertion of phasic 2°VN into local vestibular networks of inhibitory interneurons reinforces the functional consequences of the intrinsic membrane properties of this particular cell type with respect to the processing of afferent sensory signals. Thus, the combination of matching intrinsic cellular and emerging network properties generates sets of neuronal elements that form adjustable, frequency-tuned filter components for separate transformation of the various dynamic aspects of head motion-related signals. The overall frequency tuning of central vestibular neurons differs between vertebrates along with variations in species-specific locomotor dynamics, thereby illustrating an ecophysiological plasticity of the involved neuronal elements. Moreover, separation into multiple, dynamically different subtypes at any neuronal level along the vestibulo-motor reflex pathways suggests an organization of head motion-related sensory-motor transformation in parallel, frequency-tuned channels. Springer-Verlag, 2011 Membrane properties nationallicence Low-pass filter nationallicence Band-pass filter nationallicence Potassium adaptation nationallicence Inhibition nationallicence Tonic nationallicence Phasic nationallicence Ion channel nationallicence Impedance nationallicence Resonance nationallicence Rössert C. Institute of Clinical Neurosciences, LMU München, Marchioninistr. 23, 81377, Munich, Germany aut Straka H. Department II, Faculty of Biology, Ludwig-Maximilians-University Munich, Grosshadernerstr. 2, 82152, Planegg, Germany aut Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 437-449 0014-4819 210:3-4<437 2011 210 221 https://doi.org/10.1007/s00221-011-2585-3 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2585-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rössert C. Institute of Clinical Neurosciences, LMU München, Marchioninistr. 23, 81377, Munich, Germany aut NATIONALLICENCE 700 1- Straka H. Department II, Faculty of Biology, Ludwig-Maximilians-University Munich, Grosshadernerstr. 2, 82152, Planegg, Germany aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 437-449 0014-4819 210:3-4<437 2011 210 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer