caa a22 4500 445350997 CHVBK 20180317142844.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00221-011-2548-8 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2548-8 Prolonged reduction of motion sickness sensitivity by visual-vestibular interaction [Elektronische Daten] [Mingjia Dai, Ted Raphan, Bernard Cohen] The angular vestibulo-ocular reflex (aVOR) and optokinetic nystagmus (OKN) were elicited simultaneously at low frequencies to study effects of habituation of the velocity storage time constant in the vestibular system on motion sickness. Twenty-nine subjects, eleven of whom were susceptible to motion sickness from common transportation, were habituated by sinusoidal rotation at 0.017Hz at peak velocities from 5 to 20°/s, while they watched a full-field OKN stimulus. The OKN stripes rotated in the same direction and at the same frequency as the subjects, but at a higher velocity. This produced an OKN opposite in direction to the aVOR response. Motion sickness sensitivity was evaluated with off-vertical axis rotation (OVAR) and by the response to transportation before and after 5days of visual-vestibular habituation. Habituation did not induce motion sickness or change the aVOR gains, but it shortened the vestibular time constants in all subjects. This greatly reduced motion sickness produced by OVAR and sensitivity to common transport in the motion susceptible subjects, which persisted for up to 18weeks. Two motion susceptible subjects who only had aVOR/OKN habituation without being tested with OVAR also became asymptomatic. Normal subjects who were not habituated had no reduction in either their aVOR time constants ormotion sickness sensitivity. The opposing aVOR/OKN stimulation, which has not been studied before, was well tolerated, and for the first time was an effective technique for rapid and prolonged habituation of motion sickness without exposure to drugs or other nauseating habituation stimuli. Springer-Verlag, 2011 Motion sickness nationallicence Habituation/adaptation nationallicence Optokinetic nystagmus (OKN) nationallicence Vestibulo-ocular reflex (aVOR) nationallicence Velocity storage nationallicence Off-vertical axis rotation (OVAR) nationallicence Nystagmus nationallicence Motion susceptible nationallicence Dai Mingjia Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, 10029, New York, NY, USA aut Raphan Ted Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, 10029, New York, NY, USA aut Cohen Bernard Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, 10029, New York, NY, USA aut Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 503-513 0014-4819 210:3-4<503 2011 210 221 https://doi.org/10.1007/s00221-011-2548-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2548-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dai Mingjia Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Raphan Ted Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Cohen Bernard Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, 10029, New York, NY, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 503-513 0014-4819 210:3-4<503 2011 210 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer