caa a22 4500 445351004 CHVBK 20180317142844.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00221-011-2589-z doi (NATIONALLICENCE)springer-10.1007/s00221-011-2589-z Motor learning in the VOR: the cerebellar component [Elektronische Daten] [Dianne Broussard, Heather Titley, Jordan Antflick, David Hampson] This paper reviews results that support a model in which memory for VOR gain is initially encoded in the flocculus, and in which cerebellar LTD and LTP are responsible for gain increases and gain decreases, respectively. We also review data suggesting that after it is encoded, motor memory can either be disrupted, possibly by a local mechanism, or else consolidated. We show that consolidation can be rapid, in which case the frequency dependence of learning is unchanged and we will argue that this is consistent with a local mechanism of consolidation. In the longer term, however, the available evidence supports the transfer of memory out of the flocculus. In new experiments reported here, we address the mechanism of memory encoding. Pharmacological evidence shows that both mGluR1 and GABAB receptors in the flocculus are necessary for gain-up, but not for gain-down learning. Immunohistochemical experiments show that the two receptors are largely segregated on different dendritic spines on Purkinje cells. Together with what is already known of the mechanisms of cerebellar LTD and LTP, our data suggest that the direction of learning may be determined by interactions among groups of spines. Our results also provide new evidence for the existence of frequency channels for vestibular signals within the cerebellar cortex. Springer-Verlag, 2011 Cerebellum nationallicence Learning nationallicence Vestibulo-ocular reflex nationallicence Vestibular nationallicence LTD nationallicence LTP nationallicence Broussard Dianne Department of Physiology, University of Toronto, Toronto, Canada aut Titley Heather Department of Physiology, University of Toronto, Toronto, Canada aut Antflick Jordan Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada aut Hampson David Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada aut Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 451-463 0014-4819 210:3-4<451 2011 210 221 https://doi.org/10.1007/s00221-011-2589-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2589-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Broussard Dianne Department of Physiology, University of Toronto, Toronto, Canada aut NATIONALLICENCE 700 1- Titley Heather Department of Physiology, University of Toronto, Toronto, Canada aut NATIONALLICENCE 700 1- Antflick Jordan Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Hampson David Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 451-463 0014-4819 210:3-4<451 2011 210 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer