caa a22 4500 445351020 CHVBK 20180317142844.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00221-011-2586-2 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2586-2 Spatial orientation of the angular vestibulo-ocular reflex (aVOR) after semicircular canal plugging and canal nerve section [Elektronische Daten] [Sergei Yakushin, Mingjia Dai, Theodore Raphan, Jun-Ichi Suzuki, Yasuko Arai, Bernard Cohen] We investigated spatial responses of the aVOR to small and large accelerations in six canal-plugged and lateral canal nerve-sectioned monkeys. The aim was to determine whether there was spatial adaptation after partial and complete loss of all inputs in a canal plane. Impulses of torques generated head thrusts of ≈3,000°/s2. Smaller accelerations of ≈300°/s2 initiated the steps of velocity (60°/s). Animals were rotated about a spatial vertical axis while upright (0°) or statically tilted fore-aft up to ±90°. Temporal aVOR yaw and roll gains were computed at every head orientation and were fit with a sinusoid to obtain the spatial gains and phases. Spatial gains peaked at ≈0° for yaw and ≈90° for roll in normal animals. After bilateral lateral canal nerve section, the spatial yaw and roll gains peaked when animals were tilted back ≈50°, to bring the intact vertical canals in the plane of rotation. Yaw and roll gains were identical in the lateral canal nerve-sectioned monkeys tested with both low- and high-acceleration stimuli. The responses were close to normal for high-acceleration thrusts in canal-plugged animals, but were significantly reduced when these animals were given step stimuli. Thus, high accelerations adequately activated the plugged canals, whereas yaw and roll spatial aVOR gains were produced only by the intact vertical canals after total loss of lateral canal input. We conclude that there is no spatial adaptation of the aVOR even after complete loss of specific semicircular canal input. Springer-Verlag, 2011 Monkey nationallicence Vestibulo-ocular reflex nationallicence Semicircular canals nationallicence Vestibular nerve nationallicence Eye movements nationallicence Cervico-ocular reflex nationallicence Yakushin Sergei Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, 10029, New York, NY, USA aut Dai Mingjia Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, 10029, New York, NY, USA aut Raphan Theodore Department of Computer and Information Science, Brooklyn College of the City University of New York, 11210, Brooklyn, NY, USA aut Suzuki Jun-Ichi Department of Otolaryngology, Teikyo University, Tokyo, Japan aut Arai Yasuko Tokyo Women's Medical College, Tokyo, Japan aut Cohen Bernard Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, 10029, New York, NY, USA aut Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 583-594 0014-4819 210:3-4<583 2011 210 221 https://doi.org/10.1007/s00221-011-2586-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2586-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yakushin Sergei Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Dai Mingjia Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Raphan Theodore Department of Computer and Information Science, Brooklyn College of the City University of New York, 11210, Brooklyn, NY, USA aut NATIONALLICENCE 700 1- Suzuki Jun-Ichi Department of Otolaryngology, Teikyo University, Tokyo, Japan aut NATIONALLICENCE 700 1- Arai Yasuko Tokyo Women's Medical College, Tokyo, Japan aut NATIONALLICENCE 700 1- Cohen Bernard Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, 10029, New York, NY, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 583-594 0014-4819 210:3-4<583 2011 210 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer