caa a22 4500 44535108X CHVBK 20180317142844.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00221-011-2551-0 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2551-0 Postural instability and fall risk in Parkinson's disease: impaired dual tasking, pacing, and bilateral coordination of gait during the "ON” medication state [Elektronische Daten] [Meir Plotnik, Nir Giladi, Yaacov Dagan, Jeffery Hausdorff] The interplay between gait and specific cognitive faculties, in particular executive function (EF) and dual tasking abilities, has been described in healthy adults and in patients with Parkinson's disease (PD). There is, however, little direct evidence on the relationship between cognitive function, gait, and fall risk in PD, especially in the "ON” state (i.e., under the influence of the anti-parkinsonian medications). To address this issue, we evaluated cognitive function and gait under usual walking and dual-task conditions in 30 patients with PD in the ON state of the medication cycle. Subjects were classified as fallers or non-fallers based on their history. A computerized battery quantified cognitive function. Gait was assessed under three conditions: (1) Usual walking, (2) While subtracting serial 3s, and (3) While subtracting serial 7s. The EF and attention scores were lower in the fallers, compared to non-fallers (P≤0.037), but general measures of cognition, e.g., memory, (P=0.341) were not. Gait speed, variability, and the bilateral coordination of gait were worse in the fallers in all conditions. The DT effects on gait variability and bilateral coordination were larger in the fallers (P=0.044, P=0.061, respectively). These results suggest that patients with PD who have a high risk of falling are more sensitive to DT effects, perhaps as a result of relatively poor EF. These cognitive and motor deficits may increase the likelihood of loss of balance during everyday attention-demanding tasks among patients with PD. Springer-Verlag, 2011 Fall risk nationallicence Parkinson's disease nationallicence Gait nationallicence Cognition nationallicence Attention nationallicence Plotnik Meir Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., 64239, Tel Aviv, Israel aut Giladi Nir Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., 64239, Tel Aviv, Israel aut Dagan Yaacov Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., 64239, Tel Aviv, Israel aut Hausdorff Jeffery Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., 64239, Tel Aviv, Israel aut Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 529-538 0014-4819 210:3-4<529 2011 210 221 https://doi.org/10.1007/s00221-011-2551-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2551-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Plotnik Meir Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., 64239, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Giladi Nir Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., 64239, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Dagan Yaacov Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., 64239, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Hausdorff Jeffery Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., 64239, Tel Aviv, Israel aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 529-538 0014-4819 210:3-4<529 2011 210 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer