caa a22 4500 445351101 CHVBK 20180317142844.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00221-011-2591-5 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2591-5 Cross-axis adaptation improves 3D vestibulo-ocular reflex alignment during chronic stimulation via a head-mounted multichannel vestibular prosthesis [Elektronische Daten] [Chenkai Dai, Gene Fridman, Bryce Chiang, Natan Davidovics, Thuy-Anh Melvin, Kathleen Cullen, Charles Della Santina] By sensing three-dimensional (3D) head rotation and electrically stimulating the three ampullary branches of a vestibular nerve to encode head angular velocity, a multichannel vestibular prosthesis (MVP) can restore vestibular sensation to individuals disabled by loss of vestibular hair cell function. However, current spread to afferent fibers innervating non-targeted canals and otolith end organs can distort the vestibular nerve activation pattern, causing misalignment between the perceived and actual axis of head rotation. We hypothesized that over time, central neural mechanisms can adapt to correct this misalignment. To test this, we rendered five chinchillas vestibular deficient via bilateral gentamicin treatment and unilaterally implanted them with a head-mounted MVP. Comparison of 3D angular vestibulo-ocular reflex (aVOR) responses during 2Hz, 50°/s peak horizontal sinusoidal head rotations in darkness on the first, third, and seventh days of continual MVP use revealed that eye responses about the intended axis remained stable (at about 70% of the normal gain) while misalignment improved significantly by the end of 1week of prosthetic stimulation. A comparable time course of improvement was also observed for head rotations about the other two semicircular canal axes and at every stimulus frequency examined (0.2-5Hz). In addition, the extent of disconjugacy between the two eyes progressively improved during the same time window. These results indicate that the central nervous system rapidly adapts to multichannel prosthetic vestibular stimulation to markedly improve 3D aVOR alignment within the first week after activation. Similar adaptive improvements are likely to occur in other species, including humans. Springer-Verlag, 2011 Vestibular nerve nationallicence Vestibular prosthesis nationallicence Vestibular implant nationallicence Vestibulo-ocular reflex, VOR, labyrinth nationallicence Bilateral vestibular deficiency nationallicence Areflexia nationallicence Adaptation nationallicence Electrical stimulation nationallicence Dai Chenkai Departments of Otolaryngology—Head & Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Ross Bldg Rm 830, 720 Rutland Ave., 21205, Baltimore, MD, USA aut Fridman Gene Departments of Otolaryngology—Head & Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Ross Bldg Rm 830, 720 Rutland Ave., 21205, Baltimore, MD, USA aut Chiang Bryce Departments of Otolaryngology—Head & Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Ross Bldg Rm 830, 720 Rutland Ave., 21205, Baltimore, MD, USA aut Davidovics Natan Departments of Otolaryngology—Head & Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Ross Bldg Rm 830, 720 Rutland Ave., 21205, Baltimore, MD, USA aut Melvin Thuy-Anh Departments of Otolaryngology—Head & Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Ross Bldg Rm 830, 720 Rutland Ave., 21205, Baltimore, MD, USA aut Cullen Kathleen Department of Physiology, McGill University, Montreal, QC, Canada aut Della Santina Charles Departments of Otolaryngology—Head & Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Ross Bldg Rm 830, 720 Rutland Ave., 21205, Baltimore, MD, USA aut Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 595-606 0014-4819 210:3-4<595 2011 210 221 https://doi.org/10.1007/s00221-011-2591-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2591-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dai Chenkai Departments of Otolaryngology—Head & Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Ross Bldg Rm 830, 720 Rutland Ave., 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Fridman Gene Departments of Otolaryngology—Head & Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Ross Bldg Rm 830, 720 Rutland Ave., 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Chiang Bryce Departments of Otolaryngology—Head & Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Ross Bldg Rm 830, 720 Rutland Ave., 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Davidovics Natan Departments of Otolaryngology—Head & Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Ross Bldg Rm 830, 720 Rutland Ave., 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Melvin Thuy-Anh Departments of Otolaryngology—Head & Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Ross Bldg Rm 830, 720 Rutland Ave., 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Cullen Kathleen Department of Physiology, McGill University, Montreal, QC, Canada aut NATIONALLICENCE 700 1- Della Santina Charles Departments of Otolaryngology—Head & Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Ross Bldg Rm 830, 720 Rutland Ave., 21205, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 210/3-4(2011-05-01), 595-606 0014-4819 210:3-4<595 2011 210 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer