caa a22 4500 445351128 CHVBK 20180317142844.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00221-011-2571-9 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2571-9 Stump nerve signals during transcranial magnetic motor cortex stimulation recorded in an amputee via longitudinal intrafascicular electrodes [Elektronische Daten] [P. Rossini, Jacopo Rigosa, Silvestro Micera, Giovanni Assenza, Luca Rossini, Florinda Ferreri] Do central and peripheral motor pathways associated with an amputated limb retain at least some functions over periods of years? This problem could be addressed by evaluating the response patterns of nerve signals from peripheral motor fibers during transcranial magnetic stimulation (TMS) of corticospinal tracts. The aim of this study was to record for the first time TMS-related responses from the nerves of a left arm stump of an amputee via intrafascicular longitudinal flexible multi-electrodes (tfLIFE4) implanted for a prosthetic hand control. After tfLIFE4 implant in the stump median and ulnar nerves, TMS impulses of increasing intensity were delivered to the contralateral motor cortex while tfLIFE4 recordings were carried out. Combining TMS of increasing intensity and tfLIFE4 electrodes recordings, motor nerve activity possibly related to the missing limb motor control and selectively triggered by brain stimulation without significant electromyographic contamination was identified. These findings are entirely original and indicate that tfLIFE4 signals are clearly driven from M1 stimulation, therefore witnessing the presence in the stump nerves of viable motor signals from the CNS possibly useful for artificial prosthesis control. Springer-Verlag, 2011 Transcranial magnetic stimulation nationallicence Intrafascicular longitudinal flexible multi-electrodes nationallicence Peripheral nerves signals nationallicence Rossini P. Department of Neurology, University Campus Bio-Medico, Via Alvaro del Portillo 200, 00100, Rome, Italy aut Rigosa Jacopo Advanced Robotics Technology and Systems Lab, Scuola Superiore Sant'Anna, Pisa, Italy aut Micera Silvestro Advanced Robotics Technology and Systems Lab, Scuola Superiore Sant'Anna, Pisa, Italy aut Assenza Giovanni Department of Neurology, University Campus Bio-Medico, Via Alvaro del Portillo 200, 00100, Rome, Italy aut Rossini Luca IRCCS S. Raffaele-Pisana, Rome and Casa di Cura S. Raffaele, Cassino, Italy aut Ferreri Florinda Department of Neurology, University Campus Bio-Medico, Via Alvaro del Portillo 200, 00100, Rome, Italy aut Experimental Brain Research Springer-Verlag 210/1(2011-04-01), 1-11 0014-4819 210:1<1 2011 210 221 https://doi.org/10.1007/s00221-011-2571-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2571-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rossini P. Department of Neurology, University Campus Bio-Medico, Via Alvaro del Portillo 200, 00100, Rome, Italy aut NATIONALLICENCE 700 1- Rigosa Jacopo Advanced Robotics Technology and Systems Lab, Scuola Superiore Sant'Anna, Pisa, Italy aut NATIONALLICENCE 700 1- Micera Silvestro Advanced Robotics Technology and Systems Lab, Scuola Superiore Sant'Anna, Pisa, Italy aut NATIONALLICENCE 700 1- Assenza Giovanni Department of Neurology, University Campus Bio-Medico, Via Alvaro del Portillo 200, 00100, Rome, Italy aut NATIONALLICENCE 700 1- Rossini Luca IRCCS S. Raffaele-Pisana, Rome and Casa di Cura S. Raffaele, Cassino, Italy aut NATIONALLICENCE 700 1- Ferreri Florinda Department of Neurology, University Campus Bio-Medico, Via Alvaro del Portillo 200, 00100, Rome, Italy aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 210/1(2011-04-01), 1-11 0014-4819 210:1<1 2011 210 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer