caa a22 4500 445351136 CHVBK 20180317142844.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00221-011-2608-0 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2608-0 Changes in the referent body location and configuration may underlie human gait, as confirmed by findings of multi-muscle activity minimizations and phase resetting [Elektronische Daten] [Anatol Feldman, Tal Krasovsky, Melanie Baniña, Anouk Lamontagne, Mindy Levin] Locomotion is presumably guided by feed-forward shifts in the referent body location in the desired direction in the environment. We propose that the difference between the actual and the referent body locations is transmitted to neurons that virtually diminish this difference by appropriately changing the referent body configuration, i.e. the body posture at which muscles reach their recruitment thresholds. Muscles are activated depending on the gap between the actual and the referent body configurations resulting in a step being made to minimize this gap. This hypothesis implies that the actual and the referent leg configurations can match each other at certain phases of the gait cycle, resulting in minimization of leg muscle activity. We found several leg configurations at which EMG minima occurred, both during forward and backward gait. It was also found that the set of limb configurations associated with EMG minima can be changed by modifying the pattern of forward and backward gait. Our hypothesis predicts that, in response to perturbations of gait, the rate of shifts in the referent body location can temporarily be changed to avoid falling. The rate influences the phase of rhythmic limb movements during gait. Therefore, following the change in the rate of the referent body location, the whole gait pattern, for all four limbs, will irreversibly be shifted in time (long-lasting and global phase resetting) with only transient changes in the gait speed, swing and stance timing and cycle duration. Aside from transient changes in the duration of the swing and/or stance phase in response to perturbation, few previous studies have documented long-lasting and global phase resetting of human gait in response to perturbation. Such resetting was a robust finding in our study. By confirming the notion that feed-forward changes in the referent body location and configuration underlie human locomotion, this study solves the classical problem in the relationship between stability of posture and gait and advances the understanding of how human locomotion involves the whole body and is accomplished in a spatial frame of reference associated with the environment. Springer-Verlag, 2011 Locomotion nationallicence Feed-forward control nationallicence Posture and gait nationallicence Multi-muscle coordination nationallicence Redundancy problems nationallicence Equilibrium-point-hypothesis nationallicence Spatial frames of reference nationallicence Feldman Anatol Department of Physiology, University of Montreal, 6300 ave Darlington, H3S 2J4, Montreal, QC, Canada aut Krasovsky Tal School of Physical and Occupational Therapy, McGill University, 3654 Promenade Sir William Osler, H3G 1Y5, Montreal, QC, Canada aut Baniña Melanie School of Physical and Occupational Therapy, McGill University, 3654 Promenade Sir William Osler, H3G 1Y5, Montreal, QC, Canada aut Lamontagne Anouk School of Physical and Occupational Therapy, McGill University, 3654 Promenade Sir William Osler, H3G 1Y5, Montreal, QC, Canada aut Levin Mindy Center for Interdisciplinary Research in Rehabilitation, Institut de réadaptation Gingras-Lindsay de Montreal and Jewish Rehabilitation Hospital, Laval, QC, Canada aut Experimental Brain Research Springer-Verlag 210/1(2011-04-01), 91-115 0014-4819 210:1<91 2011 210 221 https://doi.org/10.1007/s00221-011-2608-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2608-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Feldman Anatol Department of Physiology, University of Montreal, 6300 ave Darlington, H3S 2J4, Montreal, QC, Canada aut NATIONALLICENCE 700 1- Krasovsky Tal School of Physical and Occupational Therapy, McGill University, 3654 Promenade Sir William Osler, H3G 1Y5, Montreal, QC, Canada aut NATIONALLICENCE 700 1- Baniña Melanie School of Physical and Occupational Therapy, McGill University, 3654 Promenade Sir William Osler, H3G 1Y5, Montreal, QC, Canada aut NATIONALLICENCE 700 1- Lamontagne Anouk School of Physical and Occupational Therapy, McGill University, 3654 Promenade Sir William Osler, H3G 1Y5, Montreal, QC, Canada aut NATIONALLICENCE 700 1- Levin Mindy Center for Interdisciplinary Research in Rehabilitation, Institut de réadaptation Gingras-Lindsay de Montreal and Jewish Rehabilitation Hospital, Laval, QC, Canada aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 210/1(2011-04-01), 91-115 0014-4819 210:1<91 2011 210 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer