caa a22 4500 445351217 CHVBK 20180317142844.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00221-011-2607-1 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2607-1 Repetitive common peroneal nerve stimulation increases ankle dorsiflexor motor evoked potentials in incomplete spinal cord lesions [Elektronische Daten] [Aiko Thompson, Brandon Lapallo, Michael Duffield, Briana Abel, Ferne Pomerantz] Plasticity of corticospinal tract (CST) activity likely plays a key role in motor function recovery after central nervous system (CNS) lesions. In non-injured adults, 30min of repetitive common peroneal nerve stimulation (rCPnS) increases CST excitability by 40-50% and the effect persists for at least 30min. The present study evaluated with transcranial magnetic stimulation (TMS) the changes in CST excitability after 30min of rCPnS in people with foot drop due to incomplete SCI. Suprathreshold rCPnS (25Hz, alternating 1s on 1s off stimulation cycle) was given for two 15-min periods, while the subject sat at rest with ankle and knee joints fixed. Before, between, and after the periods of stimulation, the tibialis anterior (TA) motor evoked potentials (MEPs) to TMS were measured at a TMS intensity that originally produced a half-maximum MEP (typically 10-20% above threshold) while the sitting subject provided 25-30% maximum voluntary TA contraction. In 10 subjects with SCI, the peak-to-peak TA MEP increased by 14±3% after rCPnS and the peak increase (+21±7%) occurred 15min after the cessation of rCPnS. The TA H-reflex, measured in separate experiments in 7 subjects, did not increase after rCPnS. The results indicate that rCPnS can increase CST excitability for the TA in people with incomplete SCI, although its effects appear smaller and shorter lasting than those found in non-injured control subjects. Such short-term plasticity in the CST excitability induced by rCPnS may contribute to long-term therapeutic effects of functional electrical stimulation previously reported in people with CNS lesions. Springer-Verlag, 2011 Foot drop nationallicence Spasticity nationallicence Electrical stimulation nationallicence Transcranial magnetic stimulation nationallicence Plasticity nationallicence Thompson Aiko Translational Neuroscience Research Program, Helen Hayes Hospital, New York State Department of Health, Route 9W, 10993, West Haverstraw, NY, USA aut Lapallo Brandon Wadsworth Center, New York State Department of Health, 12201-0509, Albany, NY, USA aut Duffield Michael Flinders University, Adelaide, SA, Australia aut Abel Briana Translational Neuroscience Research Program, Helen Hayes Hospital, New York State Department of Health, Route 9W, 10993, West Haverstraw, NY, USA aut Pomerantz Ferne Translational Neuroscience Research Program, Helen Hayes Hospital, New York State Department of Health, Route 9W, 10993, West Haverstraw, NY, USA aut Experimental Brain Research Springer-Verlag 210/1(2011-04-01), 143-152 0014-4819 210:1<143 2011 210 221 https://doi.org/10.1007/s00221-011-2607-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2607-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thompson Aiko Translational Neuroscience Research Program, Helen Hayes Hospital, New York State Department of Health, Route 9W, 10993, West Haverstraw, NY, USA aut NATIONALLICENCE 700 1- Lapallo Brandon Wadsworth Center, New York State Department of Health, 12201-0509, Albany, NY, USA aut NATIONALLICENCE 700 1- Duffield Michael Flinders University, Adelaide, SA, Australia aut NATIONALLICENCE 700 1- Abel Briana Translational Neuroscience Research Program, Helen Hayes Hospital, New York State Department of Health, Route 9W, 10993, West Haverstraw, NY, USA aut NATIONALLICENCE 700 1- Pomerantz Ferne Translational Neuroscience Research Program, Helen Hayes Hospital, New York State Department of Health, Route 9W, 10993, West Haverstraw, NY, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 210/1(2011-04-01), 143-152 0014-4819 210:1<143 2011 210 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer