caa a22 4500 445351241 CHVBK 20180317142844.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00221-011-2604-4 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2604-4 Sinusoidal galvanic vestibular stimulation (sGVS) induces a vasovagal response in the rat [Elektronische Daten] [Bernard Cohen, Giorgio Martinelli, Dmitri Ogorodnikov, Yongqing Xiang, Theodore Raphan, Gay Holstein, Sergei Yakushin] Blood pressure (BP) and heart rate (HR) were studied in isoflurane-anesthetized Long-Evans rats during sinusoidal galvanic vestibular stimulation (sGVS) and sinusoidal oscillation in pitch to characterize vestibular influences on autonomic control of BP and HR. sGVS was delivered binaurally via Ag/AgCl needle electrodes inserted over the mastoids at stimulus frequencies 0.008-0.4Hz. Two processes affecting BP and HR were induced by sGVS: 1) a transient drop in BP (≈15-20mmHg) and HR (≈3 beat*s−1), followed by a slow recovery over 1-6min; and 2) inhibitory modulations in BP (≈4.5mmHg/g) and HR (≈0.15 beats*s−1/g) twice in each stimulus cycle. The BP and HR modulations were approximately in-phase with each other and were best evoked by low stimulus frequencies. A wavelet analysis indicated significant energies in BP and HR at scales related to twice and four times the stimulus frequency bands. BP and HR were also modulated by oscillation in pitch at frequencies 0.025-0.5Hz. Sensitivities at 0.025Hz were ≈4.5mmHg/g (BP) and ≈0.17 beat*s−1/g (HR) for pitches of 20-90°. The tilt-induced BP and HR modulations were out-of-phase, but the frequencies at which responses were elicited by tilt and sGVS were the same. The results show that the sGVS-induced responses, which likely originate in the otolith organs, can exert a powerful inhibitory effect on both BP and HR at low frequencies. These responses have a striking resemblance to human vasovagal responses. Thus, sGVS-activated rats can potentially serve as a useful experimental model of the vasovagal response in humans. Springer-Verlag, 2011 Otolith organs nationallicence Vertical semicircular canals nationallicence Autonomic nationallicence Heart rate nationallicence Blood pressure nationallicence Cohen Bernard Department of Neurology, Mount Sinai School of Medicine, Box 1135 1 East 100th Street, 10029, New York, NY, USA aut Martinelli Giorgio Department of Neurology, Mount Sinai School of Medicine, Box 1135 1 East 100th Street, 10029, New York, NY, USA aut Ogorodnikov Dmitri Department of Neurology, Mount Sinai School of Medicine, Box 1135 1 East 100th Street, 10029, New York, NY, USA aut Xiang Yongqing Department of Computer and Information Sciences, Brooklyn College of the City University of New York, 11210, Brooklyn, NY, USA aut Raphan Theodore Department of Computer and Information Sciences, Brooklyn College of the City University of New York, 11210, Brooklyn, NY, USA aut Holstein Gay Department of Neurology, Mount Sinai School of Medicine, Box 1135 1 East 100th Street, 10029, New York, NY, USA aut Yakushin Sergei Department of Neurology, Mount Sinai School of Medicine, Box 1135 1 East 100th Street, 10029, New York, NY, USA aut Experimental Brain Research Springer-Verlag 210/1(2011-04-01), 45-55 0014-4819 210:1<45 2011 210 221 https://doi.org/10.1007/s00221-011-2604-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2604-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cohen Bernard Department of Neurology, Mount Sinai School of Medicine, Box 1135 1 East 100th Street, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Martinelli Giorgio Department of Neurology, Mount Sinai School of Medicine, Box 1135 1 East 100th Street, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Ogorodnikov Dmitri Department of Neurology, Mount Sinai School of Medicine, Box 1135 1 East 100th Street, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Xiang Yongqing Department of Computer and Information Sciences, Brooklyn College of the City University of New York, 11210, Brooklyn, NY, USA aut NATIONALLICENCE 700 1- Raphan Theodore Department of Computer and Information Sciences, Brooklyn College of the City University of New York, 11210, Brooklyn, NY, USA aut NATIONALLICENCE 700 1- Holstein Gay Department of Neurology, Mount Sinai School of Medicine, Box 1135 1 East 100th Street, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Yakushin Sergei Department of Neurology, Mount Sinai School of Medicine, Box 1135 1 East 100th Street, 10029, New York, NY, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 210/1(2011-04-01), 45-55 0014-4819 210:1<45 2011 210 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer