caa a22 4500 445351373 CHVBK 20180317142845.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00221-011-2633-z doi (NATIONALLICENCE)springer-10.1007/s00221-011-2633-z Improving balance function using vestibular stochastic resonance: optimizing stimulus characteristics [Elektronische Daten] [Ajitkumar Mulavara, Matthew Fiedler, Igor Kofman, Scott Wood, Jorge Serrador, Brian Peters, Helen Cohen, Millard Reschke, Jacob Bloomberg] Stochastic resonance (SR) is a phenomenon whereby the response of a non-linear system to a weak periodic input signal is optimized by the presence of a particular non-zero level of noise. Stochastic resonance using imperceptible stochastic vestibular electrical stimulation, when applied to normal young and elderly subjects, has been shown to significantly improve ocular stabilization reflexes in response to whole-body tilt; improved balance performance during postural disturbances and optimize covariance between the weak input periodic signals introduced via venous blood pressure receptors and the heart rate responses. In our study, 15 subjects stood on a compliant surface with their eyes closed. They were given low-amplitude binaural bipolar stochastic electrical stimulation of the vestibular organs in two frequency ranges of 1-2 and 0-30Hz over the amplitude range of 0 to ±700μA. Subjects were instructed to maintain an upright stance during 43-s trials, which consisted of baseline (zero amplitude) and stimulation (non-zero amplitude) periods. Measures of stability of the head and trunk using inertial motion unit sensors attached to these segments and the whole body using a force plate were measured and quantified in the mediolateral plane. Using a multivariate optimization criterion, our results show that the low levels of vestibular stimulation given to the vestibular organs improved balance performance in normal healthy subjects in the range of 5-26% consistent with the stochastic resonance phenomenon. In our study, 8 of 15 and 10 of 15 subjects were responsive for the 1-2- and 0-30-Hz stimulus signals, respectively. The improvement in balance performance did not differ significantly between the stimulations in the two frequency ranges. The amplitude of optimal stimulus for improving balance performance was predominantly in the range of ±100 to ±400μA. A device based on SR stimulation of the vestibular system might be useful as either a training modality to enhance adaptability or skill acquisition, or as a miniature patch-type stimulator that may be worn by people with disabilities due to aging or disease to improve posture and locomotion function. Springer-Verlag, 2011 Stochastic resonance nationallicence Balance nationallicence Vestibular stimulation nationallicence Electrical stimulation nationallicence Mulavara Ajitkumar Universities Space Research Association, 2101 NASA Parkway, Mail Code: SK/B272, 77058, Houston, TX, USA aut Fiedler Matthew Wyle Integrated Science and Engineering Group, Houston, TX, USA aut Kofman Igor Wyle Integrated Science and Engineering Group, Houston, TX, USA aut Wood Scott Universities Space Research Association, 2101 NASA Parkway, Mail Code: SK/B272, 77058, Houston, TX, USA aut Serrador Jorge Department of Veterans Affairs, NJ Healthcare System, East Orange, NJ, USA aut Peters Brian Wyle Integrated Science and Engineering Group, Houston, TX, USA aut Cohen Helen Baylor College of Medicine, Houston, TX, USA aut Reschke Millard NASA Johnson Space Center, Houston, TX, USA aut Bloomberg Jacob NASA Johnson Space Center, Houston, TX, USA aut Experimental Brain Research Springer-Verlag 210/2(2011-04-01), 303-312 0014-4819 210:2<303 2011 210 221 https://doi.org/10.1007/s00221-011-2633-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2633-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mulavara Ajitkumar Universities Space Research Association, 2101 NASA Parkway, Mail Code: SK/B272, 77058, Houston, TX, USA aut NATIONALLICENCE 700 1- Fiedler Matthew Wyle Integrated Science and Engineering Group, Houston, TX, USA aut NATIONALLICENCE 700 1- Kofman Igor Wyle Integrated Science and Engineering Group, Houston, TX, USA aut NATIONALLICENCE 700 1- Wood Scott Universities Space Research Association, 2101 NASA Parkway, Mail Code: SK/B272, 77058, Houston, TX, USA aut NATIONALLICENCE 700 1- Serrador Jorge Department of Veterans Affairs, NJ Healthcare System, East Orange, NJ, USA aut NATIONALLICENCE 700 1- Peters Brian Wyle Integrated Science and Engineering Group, Houston, TX, USA aut NATIONALLICENCE 700 1- Cohen Helen Baylor College of Medicine, Houston, TX, USA aut NATIONALLICENCE 700 1- Reschke Millard NASA Johnson Space Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Bloomberg Jacob NASA Johnson Space Center, Houston, TX, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 210/2(2011-04-01), 303-312 0014-4819 210:2<303 2011 210 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer