caa a22 4500 445351934 CHVBK 20180317142846.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00221-011-2685-0 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2685-0 Rhythmic movement in Parkinson's disease: effects of visual feedback and medication state [Elektronische Daten] [S. Levy-Tzedek, H. Krebs, J. Arle, J. Shils, H. Poizner] Previous studies examining discrete movements of Parkinson's disease (PD) patients have found that in addition to performing movements that were slower than those of control participants, they exhibit specific deficits in movement coordination and in sensorimotor integration required to accurately guide movements. With medication, movement speed was normalized, but the coordinative aspects of movement were not. This led to the hypothesis that dopaminergic medication more readily compensates for intensive aspects of movement (such as speed), than for coordinative aspects (such as coordination of different limb segments) (Schettino et al., Exp Brain Res 168:186-202, 2006). We tested this hypothesis on rhythmic, continuous movements of the forearm. In our task, target peak speed and amplitude, availability of visual feedback, and medication state (on/off) were varied. We found, consistent with the discrete-movement results, that peak speed (intensive aspect) was normalized by medication, while accuracy, which required coordination of speed and amplitude modulation (coordinative aspect), was not normalized by dopaminergic treatment. However, our findings that amplitude, an intensive aspect of movement, was also not normalized by medication, suggests that a simple pathway gain increase does not act to remediate all intensive aspects of movement to the same extent. While it normalized movement peak speed, it did not normalize movement amplitude. Furthermore, we found that when visual feedback was not available, all participants (PD and controls) made faster movements. The effects of dopaminergic medication and availability of visual feedback on movement speed were additive. The finding that movement speed uniformly increased both in the PD and the control groups suggests that visual feedback may be necessary for calibration of peak speed, otherwise underestimated by the motor control system. Springer-Verlag, 2011 Parkinson's disease nationallicence Sensorimotor integration nationallicence Basal ganglia nationallicence Visual feedback nationallicence Motor control nationallicence Bradykinesia nationallicence Levy-Tzedek S. Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, MA, USA aut Krebs H. Mechanical Engineering Department, Massachusetts Institute of Technology, Cambridge, MA, USA aut Arle J. Neurosurgery Department, Lahey Clinic, Burlington, MA, USA aut Shils J. Intraoperative Neurophysiology Department, Lahey Clinic, Burlington, MA, USA aut Poizner H. Institute for Neural Computation, University of California, San Diego, CA, USA aut Experimental Brain Research Springer-Verlag 211/2(2011-06-01), 277-286 0014-4819 211:2<277 2011 211 221 https://doi.org/10.1007/s00221-011-2685-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2685-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Levy-Tzedek S. Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Krebs H. Mechanical Engineering Department, Massachusetts Institute of Technology, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Arle J. Neurosurgery Department, Lahey Clinic, Burlington, MA, USA aut NATIONALLICENCE 700 1- Shils J. Intraoperative Neurophysiology Department, Lahey Clinic, Burlington, MA, USA aut NATIONALLICENCE 700 1- Poizner H. Institute for Neural Computation, University of California, San Diego, CA, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 211/2(2011-06-01), 277-286 0014-4819 211:2<277 2011 211 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer