caa a22 4500 445351942 CHVBK 20180317142846.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00221-011-2666-3 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2666-3 Theta synchronization between the hippocampus and the nucleus incertus in urethane-anesthetized rats [Elektronische Daten] [Ana Cervera-Ferri, Juan Guerrero-Martínez, Manuel Bataller-Mompeán, Alida Taberner-Cortes, Joana Martínez-Ricós, Amparo Ruiz-Torner, Vicent Teruel-Martí] Oscillatory coupling between distributed areas can constitute a mechanism for neuronal integration. Theta oscillations provide temporal windows for hippocampal processing and only appear during certain active states of animals. Since previous studies have demonstrated that nucleus incertus (NI) contributes to the generation of hippocampal theta activity, in this paper, we evaluated the oscillatory coupling between both structures. We compared hippocampal and NI field potentials that were simultaneously recorded in urethane-anesthetized rats. Electrical and cholinergic stimulations of the reticularis pontis oralis nucleus have been used as hippocampal theta generation models. The spectral analyses reveal that electrical stimulation induced an increase in theta oscillations in both channels, whose frequencies depended on the intensity of stimulation. The intensity range used simultaneously increased the normalized spectral energy in the fast theta band (6-12Hz) in HPC and NI. Frequencies within the theta range were found to be very similar in both channels. In order to validate coupling, spectral coherence was inspected. The data reveal that coherence in the high theta band also increased while stimuli were applied. Cholinergic activation progressively increased the main frequency in both structures to reach an asymptotic period with stable peak frequency in the low theta range (3-6Hz), which could be first observed in NI and lasted about 1,500s. Coherence in this band reached values close to 1. Taken together, these results support an electrophysiological and functional coupling between the hippocampus and the reticular formation, suggesting NI to be part of a distributed network working at theta frequencies. Springer-Verlag, 2011 Theta rhythm nationallicence Oscillations nationallicence Medial septum nationallicence Hippocampus nationallicence Brainstem nationallicence Cervera-Ferri Ana Departament d'Anatomia i Embriologia Humana, Facultat de Medicina, Universitat de València, Avd. Blasco Ibañez, 15, 46010, Valencia, Spain aut Guerrero-Martínez Juan Grupo de Procesado Digital de Señales, Departament d'Enginyeria Electrònica Facultat de Física, Universitat de València, Doctor Moliner 50, Burjassot, Valencia, Spain aut Bataller-Mompeán Manuel Grupo de Procesado Digital de Señales, Departament d'Enginyeria Electrònica Facultat de Física, Universitat de València, Doctor Moliner 50, Burjassot, Valencia, Spain aut Taberner-Cortes Alida Departament d'Anatomia i Embriologia Humana, Facultat de Medicina, Universitat de València, Avd. Blasco Ibañez, 15, 46010, Valencia, Spain aut Martínez-Ricós Joana Departament d'Anatomia i Embriologia Humana, Facultat de Medicina, Universitat de València, Avd. Blasco Ibañez, 15, 46010, Valencia, Spain aut Ruiz-Torner Amparo Departament d'Anatomia i Embriologia Humana, Facultat de Medicina, Universitat de València, Avd. Blasco Ibañez, 15, 46010, Valencia, Spain aut Teruel-Martí Vicent Departament d'Anatomia i Embriologia Humana, Facultat de Medicina, Universitat de València, Avd. Blasco Ibañez, 15, 46010, Valencia, Spain aut Experimental Brain Research Springer-Verlag 211/2(2011-06-01), 177-192 0014-4819 211:2<177 2011 211 221 https://doi.org/10.1007/s00221-011-2666-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2666-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cervera-Ferri Ana Departament d'Anatomia i Embriologia Humana, Facultat de Medicina, Universitat de València, Avd. Blasco Ibañez, 15, 46010, Valencia, Spain aut NATIONALLICENCE 700 1- Guerrero-Martínez Juan Grupo de Procesado Digital de Señales, Departament d'Enginyeria Electrònica Facultat de Física, Universitat de València, Doctor Moliner 50, Burjassot, Valencia, Spain aut NATIONALLICENCE 700 1- Bataller-Mompeán Manuel Grupo de Procesado Digital de Señales, Departament d'Enginyeria Electrònica Facultat de Física, Universitat de València, Doctor Moliner 50, Burjassot, Valencia, Spain aut NATIONALLICENCE 700 1- Taberner-Cortes Alida Departament d'Anatomia i Embriologia Humana, Facultat de Medicina, Universitat de València, Avd. Blasco Ibañez, 15, 46010, Valencia, Spain aut NATIONALLICENCE 700 1- Martínez-Ricós Joana Departament d'Anatomia i Embriologia Humana, Facultat de Medicina, Universitat de València, Avd. Blasco Ibañez, 15, 46010, Valencia, Spain aut NATIONALLICENCE 700 1- Ruiz-Torner Amparo Departament d'Anatomia i Embriologia Humana, Facultat de Medicina, Universitat de València, Avd. Blasco Ibañez, 15, 46010, Valencia, Spain aut NATIONALLICENCE 700 1- Teruel-Martí Vicent Departament d'Anatomia i Embriologia Humana, Facultat de Medicina, Universitat de València, Avd. Blasco Ibañez, 15, 46010, Valencia, Spain aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 211/2(2011-06-01), 177-192 0014-4819 211:2<177 2011 211 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer