caa a22 4500 445351985 CHVBK 20180317142846.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00221-011-2674-3 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2674-3 Rapid motor responses quickly integrate visuospatial task constraints [Elektronische Daten] [Lu Yang, Jonathan Michaels, J. Pruszynski, Stephen Scott] We have recently shown that subjects can appropriately modulate their rapid motor responses (traditionally termed reflexes) to move their hand to a spatial target when the target is displayed ~2s before a mechanical perturbation (Pruszynski et al. in J Neurophysiol 100:224-238, 2008). The goal of this study was to investigate how quickly visual information can be used to modulate rapid motor responses to an impending mechanical perturbation. Following a 2s to 10ms target preview delay (PD), a perturbation either displaced the subject's hand into or out of the previewed target. We also included a condition, where the target appeared after perturbation onset (target PD=+90ms). In all cases, subjects were instructed to react as quickly as possible to the perturbation by reaching into the displayed target. Our results indicate that subjects began to incorporate visual information into their rapid motor responses with PDs as small as 70ms. Interestingly, subjects reacted faster when the target was presented ~150ms before the perturbation than when they had 2s to prepare a response. Using receiver operative characteristic (ROC) analysis, we examined modulation of muscle activity as a function of preview delay in three predefined epochs. No modulation was found in the short-latency epoch (R1; 20-45ms). In contrast, both the long-latency (45-105ms) and voluntary (120-180ms) epochs were modulated at essentially the same time, 140ms from visual presentation of the target to the beginning of each respective epoch. Springer-Verlag, 2011 Reflex nationallicence Visual integration nationallicence Long-latency response nationallicence EMG nationallicence Task-dependent nationallicence Upper limb nationallicence Yang Lu Center for Neuroscience Studies, Queen's University, Room 219, Botterell Hall, K7L 3N6, Kingston, ON, Canada aut Michaels Jonathan Center for Neuroscience Studies, Queen's University, Room 219, Botterell Hall, K7L 3N6, Kingston, ON, Canada aut Pruszynski J. Center for Neuroscience Studies, Queen's University, Room 219, Botterell Hall, K7L 3N6, Kingston, ON, Canada aut Scott Stephen Center for Neuroscience Studies, Queen's University, Room 219, Botterell Hall, K7L 3N6, Kingston, ON, Canada aut Experimental Brain Research Springer-Verlag 211/2(2011-06-01), 231-242 0014-4819 211:2<231 2011 211 221 https://doi.org/10.1007/s00221-011-2674-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2674-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Lu Center for Neuroscience Studies, Queen's University, Room 219, Botterell Hall, K7L 3N6, Kingston, ON, Canada aut NATIONALLICENCE 700 1- Michaels Jonathan Center for Neuroscience Studies, Queen's University, Room 219, Botterell Hall, K7L 3N6, Kingston, ON, Canada aut NATIONALLICENCE 700 1- Pruszynski J. Center for Neuroscience Studies, Queen's University, Room 219, Botterell Hall, K7L 3N6, Kingston, ON, Canada aut NATIONALLICENCE 700 1- Scott Stephen Center for Neuroscience Studies, Queen's University, Room 219, Botterell Hall, K7L 3N6, Kingston, ON, Canada aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 211/2(2011-06-01), 231-242 0014-4819 211:2<231 2011 211 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer