caa a22 4500 445352035 CHVBK 20180317142847.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00221-011-2785-x doi (NATIONALLICENCE)springer-10.1007/s00221-011-2785-x Head position modulates optokinetic nystagmus [Elektronische Daten] [V. Pettorossi, A. Ferraresi, F. Botti, R. Panichi, N. Barmack] Orientation and movement relies on both visual and vestibular information mapped in separate coordinate systems. Here, we examine how coordinate systems interact to guide eye movements of rabbits. We exposed rabbits to continuous horizontal optokinetic stimulation (HOKS) at 5°/s to evoke horizontal eye movements, while they were statically or dynamically roll-tilted about the longitudinal axis. During monocular or binocular HOKS, when the rabbit was roll-tilted 30° onto the side of the eye stimulated in the posterior→anterior (P→A) direction, slow phase eye velocity (SPEV) increased by 3.5-5°/s. When the rabbit was roll-tilted 30° onto the side of the eye stimulated in the A→P direction, SPEV decreased to ~2.5°/s. We also tested the effect of roll-tilt after prolonged optokinetic stimulation had induced a negative optokinetic afternystagmus (OKAN II). In this condition, the SPEV occurred in the dark, "open loop.” Modulation of SPEV of OKAN II depended on the direction of the nystagmus and was consistent with that observed during "closed loop” HOKS. Dynamic roll-tilt influenced SPEV evoked by HOKS in a similar way. The amplitude and the phase of SPEV depended on the frequency of vestibular oscillation and on HOKS velocity. We conclude that the change in the linear acceleration of the gravity vector with respect to the head during roll-tilt modulates the gain of SPEV depending on its direction. This modulation improves gaze stability at different image retinal slip velocities caused by head roll-tilt during centric or eccentric head movement. Springer-Verlag, 2011 Optokinetic reflex nationallicence Gravity nationallicence Gaze stability nationallicence Head tilt nationallicence Pettorossi V. Department of Internal Medicine, Section of Human Physiology, Via del Giochetto, 06126, Perugia, Italy aut Ferraresi A. Department of Internal Medicine, Section of Human Physiology, Via del Giochetto, 06126, Perugia, Italy aut Botti F. Department of Internal Medicine, Section of Human Physiology, Via del Giochetto, 06126, Perugia, Italy aut Panichi R. Department of Internal Medicine, Section of Human Physiology, Via del Giochetto, 06126, Perugia, Italy aut Barmack N. Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR, USA aut Experimental Brain Research Springer-Verlag 213/1(2011-08-01), 141-152 0014-4819 213:1<141 2011 213 221 https://doi.org/10.1007/s00221-011-2785-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2785-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pettorossi V. Department of Internal Medicine, Section of Human Physiology, Via del Giochetto, 06126, Perugia, Italy aut NATIONALLICENCE 700 1- Ferraresi A. Department of Internal Medicine, Section of Human Physiology, Via del Giochetto, 06126, Perugia, Italy aut NATIONALLICENCE 700 1- Botti F. Department of Internal Medicine, Section of Human Physiology, Via del Giochetto, 06126, Perugia, Italy aut NATIONALLICENCE 700 1- Panichi R. Department of Internal Medicine, Section of Human Physiology, Via del Giochetto, 06126, Perugia, Italy aut NATIONALLICENCE 700 1- Barmack N. Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 213/1(2011-08-01), 141-152 0014-4819 213:1<141 2011 213 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer