caa a22 4500 445352221 CHVBK 20180317142847.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00221-011-2669-0 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2669-0 Investigating human audio-visual object perception with a combination of hypothesis-generating and hypothesis-testing fMRI analysis tools [Elektronische Daten] [Marcus Naumer, Jasper van den Bosch, Michael Wibral, Axel Kohler, Wolf Singer, Jochen Kaiser, Vincent van de Ven, Lars Muckli] Primate multisensory object perception involves distributed brain regions. To investigate the network character of these regions of the human brain, we applied data-driven group spatial independent component analysis (ICA) to a functional magnetic resonance imaging (fMRI) data set acquired during a passive audio-visual (AV) experiment with common object stimuli. We labeled three group-level independent component (IC) maps as auditory (A), visual (V), and AV, based on their spatial layouts and activation time courses. The overlap between these IC maps served as definition of a distributed network of multisensory candidate regions including superior temporal, ventral occipito-temporal, posterior parietal and prefrontal regions. During an independent second fMRI experiment, we explicitly tested their involvement in AV integration. Activations in nine out of these twelve regions met the max-criterion (A<AV>V) for multisensory integration. Comparison of this approach with a general linear model-based region-of-interest definition revealed its complementary value for multisensory neuroimaging. In conclusion, we estimated functional networks of uni- and multisensory functional connectivity from one dataset and validated their functional roles in an independent dataset. These findings demonstrate the particular value of ICA for multisensory neuroimaging research and using independent datasets to test hypotheses generated from a data-driven analysis. The Author(s), 2011 Crossmodal nationallicence Functional connectivity nationallicence Functional magnetic resonance imaging nationallicence Independent component analysis nationallicence Multisensory nationallicence Object perception nationallicence Naumer Marcus Crossmodal Neuroimaging Lab, Institute of Medical Psychology, Goethe-University of Frankfurt, Heinrich-Hoffmann-Strasse 10, 60528, Frankfurt am Main, Germany aut van den Bosch Jasper Crossmodal Neuroimaging Lab, Institute of Medical Psychology, Goethe-University of Frankfurt, Heinrich-Hoffmann-Strasse 10, 60528, Frankfurt am Main, Germany aut Wibral Michael Brain Imaging Center, Goethe-University, Frankfurt am Main, Germany aut Kohler Axel Department of Psychiatric Neurophysiology, University Hospital of Psychiatry, Bern, Switzerland aut Singer Wolf Max Planck Institute for Brain Research, Frankfurt am Main, Germany aut Kaiser Jochen Crossmodal Neuroimaging Lab, Institute of Medical Psychology, Goethe-University of Frankfurt, Heinrich-Hoffmann-Strasse 10, 60528, Frankfurt am Main, Germany aut van de Ven Vincent Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands aut Muckli Lars Centre for Cognitive Neuroimaging (CCNi), Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK aut Experimental Brain Research Springer-Verlag 213/2-3(2011-09-01), 309-320 0014-4819 213:2-3<309 2011 213 221 https://doi.org/10.1007/s00221-011-2669-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2669-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Naumer Marcus Crossmodal Neuroimaging Lab, Institute of Medical Psychology, Goethe-University of Frankfurt, Heinrich-Hoffmann-Strasse 10, 60528, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- van den Bosch Jasper Crossmodal Neuroimaging Lab, Institute of Medical Psychology, Goethe-University of Frankfurt, Heinrich-Hoffmann-Strasse 10, 60528, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- Wibral Michael Brain Imaging Center, Goethe-University, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- Kohler Axel Department of Psychiatric Neurophysiology, University Hospital of Psychiatry, Bern, Switzerland aut NATIONALLICENCE 700 1- Singer Wolf Max Planck Institute for Brain Research, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- Kaiser Jochen Crossmodal Neuroimaging Lab, Institute of Medical Psychology, Goethe-University of Frankfurt, Heinrich-Hoffmann-Strasse 10, 60528, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- van de Ven Vincent Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Muckli Lars Centre for Cognitive Neuroimaging (CCNi), Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 213/2-3(2011-09-01), 309-320 0014-4819 213:2-3<309 2011 213 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer