caa a22 4500 445352396 CHVBK 20180317142848.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00221-011-2791-z doi (NATIONALLICENCE)springer-10.1007/s00221-011-2791-z Intense training overcomes effects of the val66met BDNF polymorphism on short-term plasticity [Elektronische Daten] [Stephanie McHughen, Kristin Pearson-Fuhrhop, Vivian Ngo, Steven Cramer] The val66met polymorphism in the brain-derived neurotrophic factor (BDNF) gene impacts activity-dependent secretion of BDNF and modifies short-term cortical plasticity. The current study examined whether sustained training overcomes polymorphism effects on short-term plasticity and also examined polymorphism effects on long-term plasticity. Twenty-four subjects completed a 12-day protocol of daily training on a marble navigation task that required intense use of the first dorsal interosseus (FDI) muscle. In parallel, transcranial magnetic stimulation (TMS) mapping was used to assess serial measures of short-term cortical motor map plasticity, plus long-term cortical motor map plasticity, of the cortical FDI map. On Day 1, subjects with the polymorphism did not show significant short-term cortical motor map plasticity over 30min of FDI activity, but subjects without the polymorphism did. After 5days of intense training, a genotype-based difference in short-term cortical motor map plasticity was no longer found, as both groups showed short-term plasticity across the 30min of FDI activity. Also, across 12days of training, map area decreased significantly, in a manner that did not vary in relation to genotype. Training of sufficient intensity and duration overcomes effects that the val66met polymorphism has on short-term cortical motor map plasticity. The polymorphism-related differences seen with short-term plasticity are not found with long-term cortical motor map plasticity. Springer-Verlag, 2011 BDNF nationallicence Plasticity nationallicence Polymorphism nationallicence Training nationallicence Transcranial magnetic stimulation nationallicence McHughen Stephanie Department of Anatomy and Neurobiology, University of California, Irvine, CA, USA aut Pearson-Fuhrhop Kristin Department of Anatomy and Neurobiology, University of California, Irvine, CA, USA aut Ngo Vivian Department of Anatomy and Neurobiology, University of California, Irvine, CA, USA aut Cramer Steven Department of Anatomy and Neurobiology, University of California, Irvine, CA, USA aut Experimental Brain Research Springer-Verlag 213/4(2011-09-01), 415-422 0014-4819 213:4<415 2011 213 221 https://doi.org/10.1007/s00221-011-2791-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2791-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McHughen Stephanie Department of Anatomy and Neurobiology, University of California, Irvine, CA, USA aut NATIONALLICENCE 700 1- Pearson-Fuhrhop Kristin Department of Anatomy and Neurobiology, University of California, Irvine, CA, USA aut NATIONALLICENCE 700 1- Ngo Vivian Department of Anatomy and Neurobiology, University of California, Irvine, CA, USA aut NATIONALLICENCE 700 1- Cramer Steven Department of Anatomy and Neurobiology, University of California, Irvine, CA, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 213/4(2011-09-01), 415-422 0014-4819 213:4<415 2011 213 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer