caa a22 4500 44535240X CHVBK 20180317142848.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00221-011-2794-9 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2794-9 Neuronal discharge patterns in the Globus Pallidus pars interna in a patient with Parkinson's disease and hemiballismus secondary to subthalamotomy [Elektronische Daten] [Daniel Cerquetti, José Obeso, Marcelo Merello] Alterations in the basal ganglia-thalamocortical "motor” circuit activity, have been proposed to explain many features associated with hypokinetic and hyperkinetic movement disorders. We describe the firing pattern of the globus pallidus pars interna in a Parkinson disease's patient who developed Hemichorea-Ballismus subsequent to ipsilateral subthalamotomy, and compare findings to those from PD patients submitted to pallidotomy while in the OFF-medication state. Single units obtained from extracellular recordings were extracted and mean discharge frequency, interspike interval and coefficient of variation (defined as Tonicity Score) were computed. Discharge density histograms, analysis of distribution and spectral analysis were also performed. Mean firing frequency showed no significant difference between PD patients in the OFF state and the patient we report. However, a significant difference in tonicity was found for this patient characterized by a regular, non-bursting firing pattern. The findings indicate that in HB caused by lesions to STN in the parkinsonian state, GPi firing rates can be similar to and firing pattern more regular than those observed in GPi of PD patients OFF-medication with intact STN. Springer-Verlag, 2011 Parkinson nationallicence Hemiballism nationallicence Subthalamotomy nationallicence Globus pallidus nationallicence Firing pattern nationallicence Basal ganglia nationallicence Dyskinesia nationallicence Subthalamic nucleus nationallicence Cerquetti Daniel Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Montañeses 2325, (1428) Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina aut Obeso José Department of Neurology, Clínica Universitaria and Medical School, Neuroscience Centre, CIMA, University of Navarra, Pamplona, Spain aut Merello Marcelo Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Montañeses 2325, (1428) Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina aut Experimental Brain Research Springer-Verlag 213/4(2011-09-01), 447-455 0014-4819 213:4<447 2011 213 221 https://doi.org/10.1007/s00221-011-2794-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2794-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cerquetti Daniel Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Montañeses 2325, (1428) Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Obeso José Department of Neurology, Clínica Universitaria and Medical School, Neuroscience Centre, CIMA, University of Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Merello Marcelo Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Montañeses 2325, (1428) Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 213/4(2011-09-01), 447-455 0014-4819 213:4<447 2011 213 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer