caa a22 4500 445352566 CHVBK 20180317142848.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00221-011-2886-6 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2886-6 Modulation of cortical motor networks following primed theta burst transcranial magnetic stimulation [Elektronische Daten] [Sebastian Doeltgen, Michael Ridding] To investigate whether priming stimulation influences the responses of intracortical inhibitory and facilitatory motor circuits to a subsequent plasticity-inducing inhibitory theta burst TMS paradigm. Using standard transcranial magnetic stimulation (TMS) procedures, MEP amplitude, short-interval intracortical inhibition (SICI), and short-interval intracortical facilitation (SICF) were assessed at baseline and 5, 20 and 30min following continuous theta burst stimulation (cTBS), intermittent TBS (iTBS), and iTBS-primed cTBS. SICI was assessed using paired-pulse TMS at inter-stimulus intervals (ISI) of 3ms (SICI3) and the latency corresponding to the latency at which SICF was minimal in each individual. SICF was assessed at ISIs corresponding to Peak 1, Trough 1, Peak 2, and Peak 3 of each individual's SICF curve. When applied alone cTBS inhibited and iTBS facilitated MEP amplitudes. iTBS-primed cTBS resulted in greater MEP inhibition than cTBS alone. There were no changes in SICF and only marginal changes in SICI following any intervention. Synapses mediating MEP generation undergo modification following iTBS-primed cTBS, possibly through mechanisms related to metaplasticity or synaptic depotentiation. A lack of substantial changes in SICI and SICF under all experimental conditions suggests that the tested rTMS paradigms may be non-optimal for inducing robust modulation of the neural elements mediating SICI and SICF across subjects. Priming stimulation may provide an approach which facilitate neuroplastic change within the human motor cortex at least in circuits responsible for MEP generation. Springer-Verlag, 2011 Short-interval intracortical inhibition (SICI) nationallicence Short-interval intracortical facilitation (SICF) nationallicence Metaplasticity nationallicence Transcranial magnetic stimulation nationallicence Theta burst stimulation nationallicence Doeltgen Sebastian The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia aut Ridding Michael The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia aut Experimental Brain Research Springer-Verlag 215/3-4(2011-12-01), 199-206 0014-4819 215:3-4<199 2011 215 221 https://doi.org/10.1007/s00221-011-2886-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2886-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Doeltgen Sebastian The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia aut NATIONALLICENCE 700 1- Ridding Michael The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 215/3-4(2011-12-01), 199-206 0014-4819 215:3-4<199 2011 215 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer