caa a22 4500 445352582 CHVBK 20180317142849.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00221-011-2887-5 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2887-5 Predictive smooth eye pursuit in a population of young men: I. Effects of age, IQ, oculomotor and cognitive tasks [Elektronische Daten] [Emmanouil Kattoulas, Nikolaos Smyrnis, Nicholas Stefanis, Dimitrios Avramopoulos, Costas Stefanis, Ioannis Evdokimidis] Smooth eye pursuit is believed to involve the integration of an extraretinal signal formed by an internal representation of the moving target and a retinal signal using the visual feedback to evaluate performance. A variation of the smooth eye pursuit paradigm (in which the moving target is occluded for a short period of time and subjects are asked to continue tracking) designed to isolate the predictive processes that drive the extraretinal signal was performed by 1,187 young men. The latency to the onset of change in pursuit speed, the time of decelerating eye-movement speed and the steady state residual gain were measured for each subject and correlated with measures of other oculomotor (closed-loop smooth eye pursuit, saccade, antisaccade, active fixation) and cognitive tasks (measuring sustained attention and working memory). Deceleration time increased with increasing age, while education, general IQ and cognitive variables had no effect on predictive pursuit performance. Predictive pursuit indices were correlated to those of closed-loop pursuit and antisaccade performance, but these correlations were very weak except for a positive correlation of residual gain to saccade frequency in the fixation task with distracters. This correlation suggested that the maintenance of active fixation is negatively correlated with the ability to maintain predictive pursuit speed. In conclusion, this study presents predictive pursuit performance in a large sample of apparently healthy individuals. Surprisingly, predictive pursuit was weakly if at all related to closed-loop pursuit or other oculomotor and cognitive tasks, supporting the usefulness of this phenotype in the study of frontal lobe integrity in normal and patient populations. Springer-Verlag, 2011 Mask pursuit nationallicence Saccade nationallicence Antisaccade nationallicence Fixation nationallicence Working memory nationallicence Attention nationallicence Kattoulas Emmanouil Cognition and Action Group, Neurology Department, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece aut Smyrnis Nikolaos Cognition and Action Group, Neurology Department, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece aut Stefanis Nicholas University Mental Health Research Institute, National and Kapodistrian University of Athens, Athens, Greece aut Avramopoulos Dimitrios McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA aut Stefanis Costas University Mental Health Research Institute, National and Kapodistrian University of Athens, Athens, Greece aut Evdokimidis Ioannis Cognition and Action Group, Neurology Department, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece aut Experimental Brain Research Springer-Verlag 215/3-4(2011-12-01), 207-218 0014-4819 215:3-4<207 2011 215 221 https://doi.org/10.1007/s00221-011-2887-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2887-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kattoulas Emmanouil Cognition and Action Group, Neurology Department, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Smyrnis Nikolaos Cognition and Action Group, Neurology Department, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Stefanis Nicholas University Mental Health Research Institute, National and Kapodistrian University of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Avramopoulos Dimitrios McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Stefanis Costas University Mental Health Research Institute, National and Kapodistrian University of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Evdokimidis Ioannis Cognition and Action Group, Neurology Department, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 215/3-4(2011-12-01), 207-218 0014-4819 215:3-4<207 2011 215 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 445352582 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer