caa a22 4500 445352590 CHVBK 20180317142849.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00221-011-2903-9 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2903-9 Dissociation of brain areas associated with force production and stabilization during manipulation of unstable objects [Elektronische Daten] [Linda Holmström, Örjan de Manzano, Brigitte Vollmer, Lea Forsman, Francisco Valero-Cuevas, Fredrik Ullén, Hans Forssberg] Multifinger dexterous manipulation of unstable or deformable objects requires control of both direction and magnitude of fingertip force vectors. Our aim was to study the neuroanatomical correlates of these two distinct control functions. Brain activity was measured using functional magnetic resonance imaging while 16 male subjects (age: 26-42, M=32, SD±4years) compressed four springs representing a 2×2 factorial design with two levels of force and instability requirements. Significant activations associated with higher instability were located bilaterally in the precentral gyri, the postcentral gyrus, and the cerebellum. In the main effect for high force, activity was found in areas located in the primary motor regions contralateral to the active hand and bilaterally in the cerebellum. An overlap in activation between the two main effects was found bilaterally in the cerebellum (lobule VI). This study not only confirms a recently described bilateral fronto-parieto-cerebellar network for manipulation of increasingly unstable objects, but critically extends our understanding by describing its differentiated modulation with both force magnitude and instability requirements. Our results, therefore, expose a previously unrecognized and context-sensitive system of brain regions that enable dexterous manipulation for different force magnitude and instability requirements of the task. Springer-Verlag, 2011 Unstable object manipulation nationallicence Precision grip nationallicence Grasping network nationallicence Motor cortex nationallicence Cerebellum nationallicence Holmström Linda Neuropediatric Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital Q2:O7, 171 76, Stockholm, Sweden aut de Manzano Örjan Neuropediatric Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital Q2:O7, 171 76, Stockholm, Sweden aut Vollmer Brigitte Neuropediatric Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital Q2:O7, 171 76, Stockholm, Sweden aut Forsman Lea Neuropediatric Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital Q2:O7, 171 76, Stockholm, Sweden aut Valero-Cuevas Francisco Division of Biokinesiology and Physical Therapy, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA aut Ullén Fredrik Neuropediatric Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital Q2:O7, 171 76, Stockholm, Sweden aut Forssberg Hans Neuropediatric Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital Q2:O7, 171 76, Stockholm, Sweden aut Experimental Brain Research Springer-Verlag 215/3-4(2011-12-01), 359-367 0014-4819 215:3-4<359 2011 215 221 https://doi.org/10.1007/s00221-011-2903-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2903-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Holmström Linda Neuropediatric Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital Q2:O7, 171 76, Stockholm, Sweden aut NATIONALLICENCE 700 1- de Manzano Örjan Neuropediatric Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital Q2:O7, 171 76, Stockholm, Sweden aut NATIONALLICENCE 700 1- Vollmer Brigitte Neuropediatric Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital Q2:O7, 171 76, Stockholm, Sweden aut NATIONALLICENCE 700 1- Forsman Lea Neuropediatric Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital Q2:O7, 171 76, Stockholm, Sweden aut NATIONALLICENCE 700 1- Valero-Cuevas Francisco Division of Biokinesiology and Physical Therapy, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Ullén Fredrik Neuropediatric Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital Q2:O7, 171 76, Stockholm, Sweden aut NATIONALLICENCE 700 1- Forssberg Hans Neuropediatric Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital Q2:O7, 171 76, Stockholm, Sweden aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 215/3-4(2011-12-01), 359-367 0014-4819 215:3-4<359 2011 215 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer