caa a22 4500 445352612 CHVBK 20180317142849.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00221-011-2888-4 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2888-4 Predictive smooth eye pursuit in a population of young men: II. Effects of schizotypy, anxiety and depression [Elektronische Daten] [Emmanouil Kattoulas, Ioannis Evdokimidis, Nicholas Stefanis, Dimitrios Avramopoulos, Costas Stefanis, Nikolaos Smyrnis] Smooth pursuit eye movement dysfunction is considered to be a valid schizophrenia endophenotype. Recent studies have tried to refine the phenotype in order to identify the specific neurophysiological deficits associated with schizophrenia. We used a variation of the smooth eye pursuit paradigm, during which the moving target is occluded for a short period of time and subjects are asked to continue tracking. This is designed to isolate the predictive processes that drive the extraretinal signal, a process previously reported to be defective in schizophrenia patients as well as their healthy relatives. In the current study, we investigated the relationship between predictive pursuit performance indices and age, education, non-verbal IQ, schizotypy and state anxiety, depression in 795 young Greek military conscripts. State anxiety was related to better predictive pursuit performance (increase in residual pursuit gain), while disorganized schizotypy was related to deficient predictive pursuit performance (decreased residual gain). This effect was independent of the effect of disorganized schizotypy on other oculomotor functions supporting the hypothesis that predictive pursuit might be specifically affected in schizophrenia spectrum disorders and could be considered as a distinct oculomotor endophenotype. Springer-Verlag, 2011 Schizophrenia nationallicence Endophenotype nationallicence Psychometric nationallicence Oculomotor nationallicence Mask pursuit nationallicence Kattoulas Emmanouil Cognition and Action Group, Neurology Department, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece aut Evdokimidis Ioannis Cognition and Action Group, Neurology Department, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece aut Stefanis Nicholas University Mental Health Research Institute, National and Kapodistrian University of Athens, Athens, Greece aut Avramopoulos Dimitrios McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA aut Stefanis Costas University Mental Health Research Institute, National and Kapodistrian University of Athens, Athens, Greece aut Smyrnis Nikolaos Cognition and Action Group, Neurology Department, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece aut Experimental Brain Research Springer-Verlag 215/3-4(2011-12-01), 219-226 0014-4819 215:3-4<219 2011 215 221 https://doi.org/10.1007/s00221-011-2888-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2888-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kattoulas Emmanouil Cognition and Action Group, Neurology Department, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Evdokimidis Ioannis Cognition and Action Group, Neurology Department, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Stefanis Nicholas University Mental Health Research Institute, National and Kapodistrian University of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Avramopoulos Dimitrios McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Stefanis Costas University Mental Health Research Institute, National and Kapodistrian University of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Smyrnis Nikolaos Cognition and Action Group, Neurology Department, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 215/3-4(2011-12-01), 219-226 0014-4819 215:3-4<219 2011 215 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 445352582 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer