caa a22 4500 44535271X CHVBK 20180317142849.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00221-011-2869-7 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2869-7 Abnormal air righting behaviour in the spontaneously hypertensive rat model of ADHD [Elektronische Daten] [Eleanor Dommett, Claire Rostron] The spontaneously hypertensive rat (SHR) is the most commonly used model of attention-deficit hyperactivity disorder (ADHD), displaying the main symptoms of the disorder which are responsive to psychostimulant treatments. Research to date has focused on behavioural tests investigating functioning of the striatum or prefrontal cortex in these rats. However, there is now evidence that the superior colliculus, a structure associated with head and eye movements, may also be dysfunctional in ADHD. Therefore, the aim of this study was to investigate whether the SHR demonstrated impairment in collicular-dependent behaviour. To this end, we examined air righting behaviour, which has previously been shown to be modulated in a height-dependent manner reliant on a functional superior colliculus. We assessed SHR, Wistar Kyotos and Wistars on static righting and air righting at 50 and 10cm drop heights. There were no differences in static righting, indicating that there were no gross motor differences that would confound air righting. Qualitative analysis of video footage of the righting did not reveal any changes previously associated with collicular damage, unique to the SHR. However, the SHR did show impairment in height-dependent modulation of righting in contrast to both control strains, such that the SHR failed to modulate righting latency according to drop height. This failure is indicative of collicular abnormality. Given that many rodent tests of attentional mechanisms involve head and eye orienting, which are heavily dependent on the colliculus, a collicular dysfunction has strong implications for the type of attentional task used in this strain. Springer-Verlag, 2011 Superior colliculus nationallicence Air righting nationallicence Attention-deficit hyperactivity disorder nationallicence Spontaneously hypertensive rat nationallicence Dommett Eleanor Department of Life Sciences, The Open University, MK7 6AA, Walton Hall, Milton Keynes, UK aut Rostron Claire Department of Life Sciences, The Open University, MK7 6AA, Walton Hall, Milton Keynes, UK aut Experimental Brain Research Springer-Verlag 215/1(2011-11-01), 45-52 0014-4819 215:1<45 2011 215 221 https://doi.org/10.1007/s00221-011-2869-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2869-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dommett Eleanor Department of Life Sciences, The Open University, MK7 6AA, Walton Hall, Milton Keynes, UK aut NATIONALLICENCE 700 1- Rostron Claire Department of Life Sciences, The Open University, MK7 6AA, Walton Hall, Milton Keynes, UK aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 215/1(2011-11-01), 45-52 0014-4819 215:1<45 2011 215 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer