caa a22 4500 445352809 CHVBK 20180317142850.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00221-011-2879-5 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2879-5 Excitability changes induced in the human auditory cortex by transcranial direct current stimulation: direct electrophysiological evidence [Elektronische Daten] [Tino Zaehle, Manuela Beretta, Lutz Jäncke, Christoph Herrmann, Pascale Sandmann] Transcranial direct current stimulation (tDCS) can systematically modify behavior by inducing changes in the underlying brain function. Objective electrophysiological evidence for tDCS-induced excitability changes has been demonstrated for the visual and somatosensory cortex, while evidence for excitability changes in the auditory cortex is lacking. In the present study, we applied tDCS over the left temporal as well as the left temporo-parietal cortex and investigated tDCS-induced effects on auditory evoked potentials after anodal, cathodal, and sham stimulation. Results show that anodal and cathodal tDCS can modify auditory cortex reactivity. Moreover, auditory evoked potentials were differentially modulated as a function of site of stimulation. While anodal tDCS over the temporal cortex increased auditory P50 amplitudes, cathodal tDCS over the temporo-parietal cortex induced larger N1 amplitudes. The results directly demonstrate excitability changes in the auditory cortex induced by active tDCS over the temporal and temporo-parietal cortex and might contribute to the understanding of mechanisms involved in the successful treatment of auditory disorders like tinnitus via tDCS. Springer-Verlag, 2011 tDCS nationallicence TES nationallicence AEP nationallicence EEG nationallicence Auditory cortex nationallicence Zaehle Tino Department of Neurology, Otto v. Guericke University, Magdeburg, Germany aut Beretta Manuela Institute of Psychology, Division of Neuropsychology, University of Zurich, Zurich, Switzerland aut Jäncke Lutz Institute of Psychology, Division of Neuropsychology, University of Zurich, Zurich, Switzerland aut Herrmann Christoph Department of Psychology, Experimental Psychology Lab, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany aut Sandmann Pascale Department of Psychology, Neuropsychology Lab, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany aut Experimental Brain Research Springer-Verlag 215/2(2011-11-01), 135-140 0014-4819 215:2<135 2011 215 221 https://doi.org/10.1007/s00221-011-2879-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2879-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zaehle Tino Department of Neurology, Otto v. Guericke University, Magdeburg, Germany aut NATIONALLICENCE 700 1- Beretta Manuela Institute of Psychology, Division of Neuropsychology, University of Zurich, Zurich, Switzerland aut NATIONALLICENCE 700 1- Jäncke Lutz Institute of Psychology, Division of Neuropsychology, University of Zurich, Zurich, Switzerland aut NATIONALLICENCE 700 1- Herrmann Christoph Department of Psychology, Experimental Psychology Lab, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany aut NATIONALLICENCE 700 1- Sandmann Pascale Department of Psychology, Neuropsychology Lab, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 215/2(2011-11-01), 135-140 0014-4819 215:2<135 2011 215 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer